Lifeng He

A common pharmacophore for cytotoxic natural products that stabilize microtubules

Iwao Ojima, Subrata Chakravarty, Tadashi Inoue et al. · Proceedings of the National Academy of Sciences · 1999 · 248 citations

Medicine, Medicinal Chemistry, Pharmacology +17

Characterization of the Taxol Binding Site on the Microtubule

Srinivasa P. S. Rao, Lifeng He, Subrata Chakravarty et al. · Journal of Biological Chemistry · 1999 · 165 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Total Synthesis of (–)‐Epothilone B: An Extension of the Suzuki Coupling Method and Insights into Structure–Activity Relationships of the Epothilones

Dai‐Shi Su, Dongfang Meng, Peter Bertinato et al. · Angewandte Chemie International Edition in English · 1997 · 163 citations

Pharmacy, Chemistry, Medicinal Chemistry +15

Remote Effects in Macrolide Formation through Ring-Forming Olefin Metathesis:  An Application to the Synthesis of Fully Active Epothilone Congeners

Dong‐Fang Meng, Dai‐Shi Su, Aaron Balog et al. · Journal of the American Chemical Society · 1997 · 163 citations

Pharmacy, Medicinal Chemistry, Pharmacology +7

Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation.

Laura Martello, Pascal Verdier‐Pinard, Heng Jia Shen et al. · PubMed · 2003 · 161 citations

Life Sciences, Biochemistry, Molecular Biology +15