Hepatic Fatty Acid Transporter Cd36 Is a Common Target of LXR, PXR, and PPARγ in Promoting Steatosis

Jie Zhou, Maria Febbraio, Taira Wada, +9

Gastroenterology

InflammationMetabolic SyndromeMolecular PhysiologyHepatologyMedicine +10

A Novel Pregnane X Receptor-mediated and Sterol Regulatory Element-binding Protein-independent Lipogenic Pathway

Jie Zhou, Yonggong Zhai, Ying Mu, +6

Journal of Biological Chemistry

A Novel Constitutive Androstane Receptor-Mediated and CYP3A-Independent Pathway of Bile Acid Detoxification

S. P. S. Saini, Junichiro Sonoda, Li Xu, +7

Molecular Pharmacology

Traditional Chinese Medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) Activate Pregnane X Receptor and Increase Warfarin Clearance in Rats

Ying Mu, Jinnan Zhang, Shimin Zhang, +8

Journal of Pharmacology and Experimental Therapeutics

PXR Ablation Alleviates Diet-Induced and Genetic Obesity and Insulin Resistance in Mice

Jinhan He, Jie Gao, Meishu Xu, +4

Diabetes

Metabolic DisorderPxr AblationMetabolic RemodelingCaloric RestrictionInsulin Signaling +20

Activation of LXRs prevents bile acid toxicity and cholestasis in female mice

Hirdesh Uppal, S. P. S. Saini, Antonio Moschetta, +8

Hepatology

Orphan Nuclear Receptor Pregnane X Receptor Sensitizes Oxidative Stress Responses in Transgenic Mice and Cancerous Cells

Haibiao Gong, Shivendra V. Singh, Sharda P. Singh, +9

Molecular Endocrinology

Lipid PeroxidationCell DeathTransgenic MiceRedox BiologyToxicological Mechanism +15

Combined loss of orphan receptors PXR and CAR heightens sensitivity to toxic bile acids in mice

Hirdesh Uppal, David Toma, S. P. S. Saini, +3

Hepatology

Pxr Null MiceLipid PeroxidationPathologyOxidative StressHepatotoxicity +16

Aryl Hydrocarbon Receptor Signaling Prevents Activation of Hepatic Stellate Cells and Liver Fibrogenesis in Mice

Jiong Yan, Hung‐Chun Tung, Sihan Li, +12

Gastroenterology

Liver FibrogenesisHepatologyHepatic Stellate CellsLiver PhysiologyAryl Hydrocarbon Receptor +13

Identification of Oxysterol 7α-Hydroxylase (Cyp7b1) as a Novel Retinoid-Related Orphan Receptor α (RORα) (NR1F1) Target Gene and a Functional Cross-Talk between RORα and Liver X Receptor (NR1H3)

Taira Wada, Hong Soon Kang, Martin Angers, +8

Molecular Pharmacology