John G. Houston

Discovery and Evaluation of BMS-708163, a Potent, Selective and Orally Bioavailable γ-Secretase Inhibitor

Kevin W. Gillman, John E. Starrett, Michael F. Parker et al. · ACS Medicinal Chemistry Letters · 2010 · 183 citations

Pharmaceutical Science, Pharmacotherapy, Pharmaceutical Chemistry +19

Synthesis and biological evaluation of a library containing potentially 1600 amides / esters. A strategy for rapid compound generation and screening.

Paul W. Smith, Justine Lai, Andrew R. Whittington et al. · Bioorganic & Medicinal Chemistry Letters · 1994 · 69 citations

Bioorganic Chemistry, Engineering, Biochemistry +8

Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat

Charles F. Albright, Randy Dockens, Jere E. Meredith et al. · Journal of Pharmacology and Experimental Therapeutics · 2012 · 63 citations

Chitin biosynthesis in Candida albicans grown in vitro and in vivo and its inhibition by nikkomycin Z

Toni A. Chapman, O. S. KINSMAN, John G. Houston · Antimicrobial Agents and Chemotherapy · 1992 · 57 citations · Full text

Biosynthesis, Engineering, Antifungal Agent +14

Application of Lean Manufacturing Concepts to Drug Discovery:  Rapid Analogue Library Synthesis

Harold N. Weller, David S. Nirschl, Edward W. Petrillo et al. · Journal of Combinatorial Chemistry · 2006 · 36 citations

Combinatorial Chemistry, Targeted Library, Medicinal Chemistry +14