Yan Lan

Enhanced preclinical antitumor activity of M7824, a bifunctional fusion protein simultaneously targeting PD-L1 and TGF-β

Yan Lan, Dong Zhang, Chunxiao Xu et al. · Science Translational Medicine · 2018 · 488 citations

Life Sciences, Immunology, Oncology +17

Simultaneous targeting of TGF-β/PD-L1 synergizes with radiotherapy by reprogramming the tumor microenvironment to overcome immune evasion

Yan Lan, Mahmoud Moustafa, Maximilian Knoll et al. · Cancer Cell · 2021 · 190 citations · Full text

Medicine, Immunology, Oncology +17

SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies†

Jonathan H. Davis, Christel Aperlo, Yue Li et al. · Protein Engineering Design and Selection · 2010 · 189 citations · Full text

Pharmacy, Immunology, Molecular Biology +17

Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality

Sònia Sabaté‐Soler, Sarah Nickels, Cláudia Saraiva et al. · Glia · 2022 · 170 citations · Full text

Medicine, Neurobiology, Neuroscience +17

The immunocytokine NHS-IL12 as a potential cancer therapeutic

Jonathan K. Fallon, Robert M. Tighe, Giorgio Kradjian et al. · Oncotarget · 2014 · 159 citations · Full text

Life Sciences, Immunology, Oncology +17