m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways

Huabing Li, Jiyu Tong, Shu Zhu, +15

Nature

Il-7/stat5/socs PathwaysCytokineT Cell HomeostasisAutoimmune DiseaseImmune Cell Development +8

Inflammasome activation in infected macrophages drives COVID-19 pathology

Esen Sefik, Rihao Qu, Caroline Junqueira, +18

Nature

InflammationHost ResponseInfected MacrophagesImmunologyChronic Inflammation +3

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity

Dietmar Herndler‐Brandstetter, Harumichi Ishigame, Ryo Shinnakasu, +13

Immunity

Autoimmune DiseaseAdaptive Immune SystemImmunologyAutoimmunityT Cell Immunity +6

Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells

Shu Zhu, Siyuan Ding, Penghua Wang, +22

Nature

InflammationMucosal ImmunologyImmunologyGastroenterologyPathology +4

Paracrine orchestration of intestinal tumorigenesis by a mesenchymal niche

Manolis Roulis, Aimilios Kaklamanos, Marina Schernthanner, +22

Nature

Colorectal CancerPathologyParacrine OrchestrationDigestive TractMedicine +4

Zero-preserving imputation of single-cell RNA-seq data

George C. Linderman, Jun Zhao, Manolis Roulis, +4

Nature Communications

EngineeringGeneticsLow-rank Matrix ApproximationTranscriptomics TechnologyGene Expression Profiling +16

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

Will Bailis, Justin A. Shyer, Jun Zhao, +12

Nature

Systems BiologyMitochondrial FunctionMitochondrial DynamicDistinct ModesMetabolism +3

Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity

Abigail Jarret, Ruaidhrí Jackson, Coco Duizer, +23

Cell

InflammationMucosal ImmunologyMedicineInnate Immune SystemImmunology +3

Removal of batch effects using distribution-matching residual networks

Uri Shaham, Kelly Stanton, Jun Zhao, +4

Bioinformatics

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

Wen Pan, Shu Zhu, Kun Qu, +17

Immunity

Tumor BiologyTumor-infiltrating Myeloid CellsMedicineMelanomaImmunology +7