Potential Role for AMP-Activated Protein Kinase in Hypoglycemia Sensing in the Ventromedial Hypothalamus

Rory J. McCrimmon, Xiaoning Fan, Yuyan Ding, +3

Diabetes

Homeostatic MechanismHypoglycemia SensingPhysiological RegulationInsulin SignalingSocial Sciences +23

Activation of AMP-Activated Protein Kinase Within the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses in Rats With Defective Counterregulation

Rory J. McCrimmon, Xiaoning Fan, Hai‐Ying Mary Cheng, +6

Diabetes

Blockade of GABAA Receptors in the Ventromedial Hypothalamus Further Stimulates Glucagon and Sympathoadrenal but Not the Hypothalamo-Pituitary-Adrenal Response to Hypoglycemia

Owen Chan, Wanling Zhu, Yuyan Ding, +2

Diabetes

Activation of ATP-Sensitive K+ Channels in the Ventromedial Hypothalamus Amplifies Counterregulatory Hormone Responses to Hypoglycemia in Normal and Recurrently Hypoglycemic Rats

Rory J. McCrimmon, Mark L. Evans, Xiaoning Fan, +6

Diabetes

Increased GABAergic Tone in the Ventromedial Hypothalamus Contributes to Suppression of Counterregulatory Reponses After Antecedent Hypoglycemia

Owen Chan, Hai‐Ying Mary Cheng, Raimund I. Herzog, +6

Diabetes

Influence of Insulin in the Ventromedial Hypothalamus on Pancreatic Glucagon Secretion In Vivo

Sachin Paranjape, Owen Chan, Wanling Zhu, +6

Diabetes

ATP-Sensitive K+ Channels Regulate the Release of GABA in the Ventromedial Hypothalamus During Hypoglycemia

Owen Chan, Marcus A. Lawson, Wanling Zhu, +2

Diabetes

Experimental PharmacologyCellular PhysiologySocial SciencesGaba LevelsNeurochemistry +14

Lactate-Induced Release of GABA in the Ventromedial Hypothalamus Contributes to Counterregulatory Failure in Recurrent Hypoglycemia and Diabetes

Owen Chan, Sachin Paranjape, Adam Horblitt, +2

Diabetes

Insulin SignalingSocial SciencesGaba LevelsGabaa Receptor AntagonistHypothalamic Peptide +21

Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia

Wanling Zhu, Daniel J. Czyzyk, Sachin Paranjape, +6

American Journal of Physiology-Endocrinology and Metabolism

Full ActivationInsulin SignalingSocial SciencesHypothalamic PeptideGaba Release +19

Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats

Owen Chan, Sachin Paranjape, Daniel J. Czyzyk, +6

Diabetes