SIRT1 Promotes Proliferation and Prevents Senescence Through Targeting LKB1 in Primary Porcine Aortic Endothelial Cells

Yi Zu, Ling Liu, Mary Y. K. Lee, +5

Circulation Research

Cyclin-Dependent Kinase 5–Mediated Hyperphosphorylation of Sirtuin-1 Contributes to the Development of Endothelial Senescence and Atherosclerosis

Bo Bai, Yan Liang, Cheng Xu, +5

Circulation

Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation

Cheng Xu, Yunfei Wang, Qiu Tu, +7

Oncogene

Tumor BiologyMitophagySurface NucleolinPancreatic CancerCell Autophagy +11

Regulation and Quality Control of Adiponectin Assembly by Endoplasmic Reticulum Chaperone ERp44

Lutz Hampe, Mazdak Radjainia, Cheng Xu, +6

Journal of Biological Chemistry

Protein FunctionProtein AssemblyBiochemistryProtein FoldingAdiponectin Assembly +8

Endothelial SIRT1 prevents adverse arterial remodeling by facilitating HERC2-mediated degradation of acetylated LKB1

Bo Bai, Andy W. C. Man, Kangmin Yang, +9

Oncotarget

Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice.

Cheng Xu, Bo Bai, Yu‐Dong Cai, +10

PubMed

Adipose Sirt1Locomotor ActivityCaloric RestrictionInsulin SignalingBiotin Contents +21

Anti-proliferative effects, cell cycle G2/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines

Da-Yong Lu, Min Huang, Cheng Xu, +8

BMC Pharmacology

Endothelial SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase in smooth muscle cells

Yumeng Guo, Cheng Xu, Andy W. C. Man, +6

Cardiovascular Research

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin

Yaqun Fang, Xiaoqin He, Pengcheng Zhang, +6

Toxins

Trehalose restores functional autophagy suppressed by high glucose

Cheng Xu, Xi Chen, Weibin Sheng, +1

Reproductive Toxicology

Cell AutophagyMitophagyFunctional AutophagyPhysiologyAutophagy +6