Discovery of Novel Bromophenol–Thiosemicarbazone Hybrids as Potent Selective Inhibitors of Poly(ADP-ribose) Polymerase-1 (PARP-1) for Use in Cancer

Chuanlong Guo, Lijun Wang, Xiuxue Li, +8

Journal of Medicinal Chemistry

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Yuan Jin, Guangshuai Qi, Yingqing Shou, +12

Journal of Hazardous Materials

High ThroughputToxicological MechanismRespiratory ToxicologyBiostatisticsToxicology +17

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo, Yufei Hou, Wanli Ma, +9

Biochemical Pharmacology

Novel MechanismAlcohol Dehydrogenase ExpressionAldehyde DehydrogenaseLiver PhysiologyGenetics +9

Ferroptosis contributes to ethanol-induced hepatic cell death via labile iron accumulation and GPx4 inactivation

Jiao Luo, Ge Song, Ningning Chen, +8

Cell Death Discovery

A Novel Bromophenol Derivative BOS-102 Induces Cell Cycle Arrest and Apoptosis in Human A549 Lung Cancer Cells via ROS-Mediated PI3K/Akt and the MAPK Signaling Pathway

Chuanlong Guo, Lijun Wang, Yue Zhao, +7

Marine Drugs

Marine Bromophenol Bis (2,3-Dibromo-4,5-dihydroxy-phenyl)-methane Inhibits the Proliferation, Migration, and Invasion of Hepatocellular Carcinoma Cells via Modulating β1-Integrin/FAK Signaling

Ning Wu, Jiao Luo, Bo Jiang, +6

Marine Drugs

Chemoprevention StrategyApoptosisHepatocellular Carcinoma CellsCell DeathCancer Biology +22

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Lin Xu, Qianwen Zhao, Jiao Luo, +10

Ecotoxicology and Environmental Safety

Metabolomic ProfilingOxidative StressMetabolic SyndromeToxicologyHepatotoxicity +19

Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors

Ning Li, Lijun Wang, Bo Jiang, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDerivative (Chemistry)BiochemistryMedicineNatural Sciences +8

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Yuan Jin, Meiyao Feng, Wanli Ma, +16

Environmental Pollution

Ahr ActivationPredictive ToxicologyForensic ToxicologyPharmacologyAdverse Outcome Pathway +7

Selectivity, cell permeability and oral availability studies of novel bromophenol derivative HPN as protein tyrosine phosphatase 1B inhibitor

Jiao Luo, Xu Qi, Bo Jiang, +7

British Journal of Pharmacology