Mark Chen

The use of 19F spectroscopy and diffusion-weighted MRI to evaluate differences in gene-dependent enzyme prodrug therapies

Daniel A. Hamstra, Kuei C. Lee, Joseph M. Tychewicz et al. · Molecular Therapy · 2004 · 77 citations · Full text

Medicine, Biochemistry, Oncology +17

Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

Jianguo Huang, Mark Chen, Melodi Javid Whitley et al. · Nature Communications · 2017 · 77 citations · Full text

Life Sciences, Genetics, Oncology +17

Overcoming Preclinical Safety Obstacles to Discover (<i>S</i>)-<i>N</i>-((1,2,3,5,6,7-Hexahydro-<i>s</i>-indacen-4-yl)carbamoyl)-6-(methylamino)-6,7-dihydro-5<i>H</i>-pyrazolo[5,1-<i>b</i>][1,3]oxazine-3-sulfonamide (GDC-2394): A Potent and Selective NLRP3 Inhibitor

Christopher McBride, Lynnie Trzoss, Davide Povero et al. · Journal of Medicinal Chemistry · 2022 · 73 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Tumor genotype dictates radiosensitization after Atm deletion in primary brainstem glioma models

Katherine Deland, Bryce Starr, Joshua S. Mercer et al. · Journal of Clinical Investigation · 2020 · 43 citations · Full text

Medicine, Genetics, Oncology +17

Genomic Status of <i>MET</i> Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors

Jacqueline D. Peacock, Matthew G. Pridgeon, Elizabeth A. Tovar et al. · Cancer Research · 2018 · 40 citations · Full text

Medicine, Molecular Genetics, Oncology +17