Integrative Genomic Analyses Reveal an Androgen-Driven Somatic Alteration Landscape in Early-Onset Prostate Cancer

Joachim Weischenfeldt, Ronald Simon, Lars Feuerbach, +56

Cancer Cell

Early-onset Prostate CancerUrologySomatic VariantGeneticsCancer Genomics +5

Histone Deacetylase Inhibitors Sensitize Prostate Cancer Cells to Agents that Produce DNA Double-Strand Breaks by Targeting Ku70 Acetylation

Chang‐Shi Chen, Yu-Chieh Wang, Po-Hsien Huang, +6

Cancer Research

Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases

Po-Hsien Huang, Chun-Han Chen, Chih-Chien Chou, +5

Molecular Pharmacology

Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma

Khelifa Arab, Laura T. Smith, Andreas Gast, +9

Carcinogenesis

RNA bisulfite sequencing reveals NSUN2-mediated suppression of epithelial differentiation in pancreatic cancer

Szu-Ying Chen, Kuan-Lin Chen, Li-Yun Ding, +11

Oncogene

Pancreatic CancerMedicineReveals Nsun2-mediated SuppressionRna BisulfiteCancer Genomics +7

Synthesis and Biological Evaluation of 1-Arylsulfonyl-5-(<i>N</i>-hydroxyacrylamide)indoles as Potent Histone Deacetylase Inhibitors with Antitumor Activity in Vivo

Mei-Jung Lai, Han-Li Huang, Shiow‐Lin Pan, +9

Journal of Medicinal Chemistry

Total Syntheses of the Histone Deacetylase Inhibitors Largazole and 2-<i>epi</i>-Largazole: Application of <i>N</i>-Heterocyclic Carbene Mediated Acylations in Complex Molecule Synthesis

Bo Wang, Po-Hsien Huang, Ching-Shih Chen, +1

The Journal of Organic Chemistry

Building BlocksMedicinal ChemistryBiosynthesisEngineeringHeterocyclic +13

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8

Hao‐Chen Wang, Yung-Lun Lin, Ching-Cheng Hsu, +7

Theranostics

Vitamin E Facilitates the Inactivation of the Kinase Akt by the Phosphatase PHLPP1

Po-Hsien Huang, Hsiao-Ching Chuang, Chih-Chien Chou, +7

Science Signaling

Chemoprevention StrategyPhosphatase Phlpp1Cancer BiologyCellular PhysiologyTumor Biology +25

TGFβ promotes mesenchymal phenotype of pancreatic cancer cells, in part, through epigenetic activation of VAV1

Po-Hsien Huang, P-J Lu, L-Y Ding, +7

Oncogene

Pancreatic CancerMesenchymal PhenotypeCell RegulationCell SignalingMedicine +9