The Small Molecule GMX1778 Is a Potent Inhibitor of NAD ⁺ Biosynthesis: Strategy for Enhanced Therapy in Nicotinic Acid Phosphoribosyltransferase 1-Deficient Tumors

Mark H. Watson, Anne Roulston, Laurent Bélec, +23

Molecular and Cellular Biology

Complement C5b-9 Membrane Attack Complex Increases Expression of Endoplasmic Reticulum Stress Proteins in Glomerular Epithelial Cells

Andrey V. Cybulsky, Tomoko Takano, Joan Papillon, +3

Journal of Biological Chemistry

Glomerular DiseaseProtein SecretionRenal PathologyImmunologyCell Death +22

A global benchmark study using affinity-based biosensors

Rebecca L. Rich, Giuseppe A. Papalia, Peter J. Flynn, +148

Analytical Biochemistry

EngineeringGlobal Benchmark StudyBioanalysisSensor DesignBiomedical Engineering +2

Proteomics Analysis of Human Obesity Reveals the Epigenetic Factor HDAC4 as a Potential Target for Obesity

Mohamed Abu‐Farha, Ali Tiss, Jehad Abubaker, +13

PLoS ONE

Epigenetic ChangeGeneticsHuman ObesityMolecular BiologyHistone Deacetylase 4 +21

Circulating angiopoietin-like protein 8 (betatrophin) association with HsCRP and metabolic syndrome

Mohamed Abu‐Farha, Jehad Abubaker, Irina Al‐Khairi, +8

Cardiovascular Diabetology

MAP kinase phosphatase DUSP1 is overexpressed in obese humans and modulated by physical exercise

Abdelkrim Khadir, Ali Tiss, Jehad Abubaker, +12

American Journal of Physiology-Endocrinology and Metabolism

Metabolic DisorderImmunologyP38 MapkMetabolic RemodelingInsulin Signaling +26

DNAJB3/HSP-40 Cochaperone Is Downregulated in Obese Humans and Is Restored by Physical Exercise

Jehad Abubaker, Ali Tiss, Mohamed Abu‐Farha, +13

PLoS ONE

Physical exercise alleviates ER stress in obese humans through reduction in the expression and release of GRP78 chaperone

Abdelkrim Khadir, Sina Kavalakatt, Jehad Abubaker, +8

Metabolism

ObesityMetabolic SyndromeEnergy HomeostasisPhysical ActivityKinesiology +11

Complement Activates the c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase in Glomerular Epithelial Cells

Hongwei Peng, Tomoko Takano, Joan Papillon, +3

The Journal of Immunology

Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes

Abdelkrim Khadir, Sina Kavalakatt, Dhanya Madhu, +4

Scientific Reports