Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

Liqiu Wang, Tao Liu, Shuai Yang, +10

Nature Communications

LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation

Zi‐Ming Ye, Shuai Yang, Yuanpeng Xia, +10

Cell Death and Disease

Miat KnockdownVascular DiseaseLncrna MiatImmunologyPathology +18

Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy

Liqiu Wang, Jing Cai, Xin Zhao, +12

Molecular Cell

InflammationCell AutophagyAnti-inflammatorySignal TransductionPalmitoylation Prevents +10

Selective autophagy controls the stability of transcription factor IRF3 to balance type I interferon production and immune suppression

Yaoxing Wu, Shouheng Jin, Qingxiang Liu, +6

Autophagy

LRRC59 modulates type I interferon signaling by restraining the SQSTM1/p62-mediated autophagic degradation of pattern recognition receptor DDX58/RIG-I

Huifang Xian, Shuai Yang, Shouheng Jin, +2

Autophagy

Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex

Sihui Cai, Chenqiu Zhang, Zhen Zhuang, +12

Signal Transduction and Targeted Therapy

USP38 Couples Histone Ubiquitination and Methylation via KDM5B to Resolve Inflammation

Zhiyao Zhao, Zexiong Su, Puping Liang, +9

Advanced Science

Palmitoylation of GPX4 via the targetable ZDHHC8 determines ferroptosis sensitivity and antitumor immunity

Liang Zhou, Guang‐Yu Lian, Tao Zhou, +9

Nature Cancer

MedicineMetalloproteinImmunologyTumor ImmunityAntitumor Immunity +6

Selective autophagy controls the stability of TBK1 via NEDD4 to balance host defense

Weihong Xie, Shouheng Jin, Chenqiu Zhang, +5

Cell Death and Differentiation

Cell AutophagyMitophagySelective AutophagySignal TransductionSignaling Pathway +7

HTLV-1 Tax impairs K63-linked ubiquitination of STING to evade host innate immunity

Jie Wang, Shuai Yang, Lu Liu, +2

Virus Research

K63-linked UbiquitinationMolecular VirologyHost Innate ImmunityHtlv-1 TaxPathogenesis +8