Defective Viral Genomes Arising In Vivo Provide Critical Danger Signals for the Triggering of Lung Antiviral Immunity

Karla Tapia, Won-keun Kim, Yan Sun, +5

PLoS Pathogens

Viral ReplicationInflammatory Lung DiseaseInnate Immune SystemViral PathogenesisImmunology +14

Immunostimulatory Defective Viral Genomes from Respiratory Syncytial Virus Promote a Strong Innate Antiviral Response during Infection in Mice and Humans

Yan Sun, Deepika Jain, Cynthia Koziol‐White, +6

PLoS Pathogens

Viral ReplicationRespiratory Virus ImmunityInflammatory Lung DiseaseRsv IdvgsLung Inflammation +12

Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

Oekyung Kim, Yan Sun, Frances W. Lai, +2

Virology

Viral ReplicationCreb-binding ProteinMolecular VirologyPathogenesisViral Pathogenesis +8

Replication defective viral genomes exploit a cellular pro-survival mechanism to establish paramyxovirus persistence

Jie Xu, Yan Sun, Yize Li, +5

Nature Communications

Activity of Uncleaved Caspase-8 Controls Anti-bacterial Immune Defense and TLR-Induced Cytokine Production Independent of Cell Death

Naomi H. Philip, Alexandra DeLaney, Lance W. Peterson, +14

PLoS Pathogens

ApoptosisImmunologyInnate Immune SystemCell DeathImmunologic Mechanism +16

Nonstructural Protein 11 of Porcine Reproductive and Respiratory Syndrome Virus Suppresses Both MAVS and RIG-I Expression as One of the Mechanisms to Antagonize Type I Interferon Production

Yan Sun, Hanzhong Ke, Mingyuan Han, +3

PLoS ONE

Viral ReplicationViral PathogenesisImmunologyInnate ImmunityImmune System +18

Real-Time Prediction of Waiting Time in the Emergency Department, Using Quantile Regression

Yan Sun, Kiok Liang Teow, Bee Hoon Heng, +2

Annals of Emergency Medicine

Real-time PredictionUsing Quantile RegressionEngineeringEmergency CarePredictive Analytics +10

Pneumococcal Capsular Polysaccharide Preparations May Contain Non-C-Polysaccharide Contaminants That Are Immunogenic

Xinhong Yu, Yan Sun, Carl E. Frasch, +2

Clinical and Diagnostic Laboratory Immunology

Highly immunostimulatory RNA derived from a Sendai virus defective viral genome

Xiomara Mercado-López, Christopher R. Cotter, Won-keun Kim, +4

Vaccine

Viral ReplicationViral EvolutionMolecular VirologyGeneticsPathogenesis +7

5-year survival and rehospitalization due to stroke recurrence among patients with hemorrhagic or ischemic strokes in Singapore

Yan Sun, Sze Haur Lee, Bee Hoon Heng, +1

BMC Neurology