Jianyu Sun

Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection

John O. Link, James G. Taylor, Lianhong Xu et al. · Journal of Medicinal Chemistry · 2013 · 290 citations

Discovery of XEN907, a spirooxindole blocker of NaV1.7 for the treatment of pain

Sultan Chowdhury, Mikhail Chafeev, Shifeng Liu et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 154 citations · Full text

Medicinal Chemistry, Pain Medicine, Medicine +6

Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms

S. Kolappan, David L. Shen, Renée Mosi et al. · Acta Crystallographica Section D Biological Crystallography · 2015 · 76 citations

Molecular Biology, Molecular Pharmacology, Structure-function Enzyme Kinetics +17

Therapeutic targeting of STING-TBK1-IRF3 signalling ameliorates chronic stress induced depression-like behaviours by modulating neuroinflammation and microglia phagocytosis

Na Duan, Yanpeng Zhang, Shuwen Tan et al. · Neurobiology of Disease · 2022 · 59 citations · Full text

The inhibition of NFкB signaling and inflammatory response as a strategy for blunting bile acid-induced hepatic and renal toxicity

Asrin Ahmadi, Hossein Niknahad, Huifeng Li et al. · Toxicology Letters · 2021 · 57 citations

Immunology, Pathology, Cell Death +17