The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

Qiang Wang, Xing Liu, Ye Cui, +6

Immunity

Signal TransductionSignaling PathwayNatural SciencesAdaptor StingTbk1 Kinase +8

Tumor microenvironment remodeling after neoadjuvant immunotherapy in non-small cell lung cancer revealed by single-cell RNA sequencing

Junjie Hu, Lele Zhang, Haoran Xia, +17

Genome Medicine

The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING

Senlin Li, Ze Hong, Zhe Wang, +18

Cell Reports

Single-cell transcriptome and antigen-immunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer

Jian Chen, Yun Tan, Fenghuan Sun, +16

Genome biology

Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

Qian Liu, Jing Zhang, Chenchen Guo, +27

Cell

Tumor BiologyMedicineBiological InsightsCancer GenomicsBronchial Neoplasm +8

SENP7 Potentiates cGAS Activation by Relieving SUMO-Mediated Inhibition of Cytosolic DNA Sensing

Ye Cui, Huansha Yu, Xin Zheng, +10

PLoS Pathogens

Molecular RegulationImmunologySignal RecognitionMolecular BiologyCgas Activation +20

Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer

Yilv Yan, Dongqing Sun, Junjie Hu, +17

Nature Genetics

Cancer ImmunosurveillanceNon-small-cell Lung CancerMedicineImmunologyCancer Genomics +8

MiR-199a-5p suppresses non-small cell lung cancer via targeting MAP3K11

Yanli Li, Detao Wang, Xue Li, +4

Journal of Cancer

Nsclc Patient TissuesMouse Nsclc TissuesCancer Cell BiologyCancer GenomicsMicrorna Detection +10

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

Lele Zhang, Ning Wei, Ye Cui, +12

PLoS Pathogens

Specific CheckpointSystems BiologySignal TransductionDeubiquitinase CyldMedicine +12

ER Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs

Wei Chen, Senlin Li, Huansha Yu, +8

PLoS Pathogens

ImmunologyMolecular BiologyInnate ImmunityInterferon GenesMolecular Research +19