Coexpression of IL7 and CCL21 Increases Efficacy of CAR-T Cells in Solid Tumors without Requiring Preconditioned Lymphodepletion

Hong Luo, Su Jingwen, Ruixin Sun, +6

Clinical Cancer Research

Olaparib Suppresses MDSC Recruitment via SDF1α/CXCR4 Axis to Improve the Anti-tumor Efficacy of CAR-T Cells on Breast Cancer in Mice

Ruixin Sun, Hong Luo, Su Jingwen, +8

Molecular Therapy

An IL-4/21 Inverted Cytokine Receptor Improving CAR-T Cell Potency in Immunosuppressive Solid-Tumor Microenvironment

Yi Wang, Hua Jiang, Hong Luo, +4

Frontiers in Immunology

FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer

Yifan Liu, Yansha Sun, Peng Wang, +7

Journal of Translational Medicine

CXCR4-modified CAR-T cells suppresses MDSCs recruitment via STAT3/NF-κB/SDF-1α axis to enhance efficacy against pancreatic cancer

Ruixin Sun, Yansha Sun, Chuanlong Wu, +8

Molecular Therapy

Antitumor efficacy of chimeric antigen receptor T cells against EGFRvIII-expressing glioblastoma in C57BL/6 mice

Muhua Chen, Ruixin Sun, Bizhi Shi, +7

Biomedicine & Pharmacotherapy

Target-Dependent Expression of IL12 by synNotch Receptor-Engineered NK92 Cells Increases the Antitumor Activities of CAR-T Cells

Hong Luo, Xiuqi Wu, Ruixin Sun, +7

Frontiers in Oncology

GPC3-targeted CAR-T cells expressing GLUT1 or AGK exhibit enhanced antitumor activity against hepatocellular carcinoma

Ruixin Sun, Yifan Liu, Yansha Sun, +5

Acta Pharmacologica Sinica

Gpc3-targeted Car-t CellsMedicineImmunologyImmune Checkpoint InhibitorLiver Cancer +5

Enforced expression of Runx3 improved CAR-T cell potency in solid tumor via enhancing resistance to activation-induced cell death

Yi Wang, Honghong Zhang, Guoxiu Du, +8

Molecular Therapy

Cell TherapyCancer ImmunosurveillanceCar-t Cell PotencyImmunologySolid Tumor +4

Chimeric anti-GPC3 sFv-CD3ε receptor-modified T cells with IL7 co-expression for the treatment of solid tumors

Yansha Sun, Yiwei Dong, Ruixin Sun, +6

Molecular Therapy — Oncolytics