21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T54f,Purpose: The aim of this study was to develop a new type of nanoparticle that enables concentrated drug release and synergistic therapy. Methods: To this end, we synthesized Ge-DOX-5-ALA/NPs, which can enter tumor tissue by the enhanced permeability and retention (EPR) effect and release drugs by utilizing matrix metalloproteinase-2 (MMP-2). Results: The Ge-DOX-5-ALA/NPs were synthesized by a single-phase coacervation method, and the hydrodynamic diameters of all nanoparticles were under 200 nm. The drug encapsulation and loading efficiency were 92%±1.13% and 6.02% ± 0.48%, respectively. Gelatin zymography was performed to detect the expression of MMP-2 in MCF-7 and Hs578Bst cells. The nanoparticle sensitivity to MMP-2 was examined by comparing the release behavior and cellular uptake in MCF-7 and Hs578Bst cells. In vitro cytotoxicity of the nanoparticles was measured by an MTT assay. An in vivo anticancer efficacy study in S180-bearing mice demonstrated that Ge-DOX-5-ALA/NPs provide a substantial curative effect. A pharmacokinetics experiment demonstrated that the nanoparticles have a sustained release effect. Conclusions: The MMP-2-triggered nanoparticles can transport drugs successfully into the tumor site and enable combined chemotherapy and photodynamic therapy.23:T50c,Steam generation via harvesting solar energy is one of the promising approaches for seawater desalination. Nowadays, organic contamination in seawater represents a great challenge that needs to be solved. Specially, low-molecular-weight organic molecules may easily pass through distillation membranes with water steam and enter freshwater sources. In this study, we develop a solar distillation membrane (DM) for contaminated seawater desalination rather than grading treatment of contaminated seawater by integrating a large-scale TiO2 nanochannel membrane with plasmonic silver nanoparticles (Ag NPs) via inhomogeneous assembling. Such incorporation enables a self-upstanding DM acting as an efficient broad-band plasmonic absorber (200–2500 nm) and possessing high solar steam efficiencies (82% at 6 kW m–2), thus driving the photothermal desalination and photocatalytic decontamination in a synchronous fashion. The resulting membranes exhibit a rapid evaporation rate (7.14 kg m–2 h–1), helping in achieving fresh water from seawater contaminated with a high concentration of organics with remarkable durability and reusability. We believe the DM proposed in this study could pave the way for a promising point-of-use device to obtain fresh water from contaminated saline water.24:T4ce,Infectious diseases caused by bacteria are a global threat to the human health. Here, we propose a solvent “irrigation” technique to endow TiO2 nanotubes (NTs) to precisely modify with functional nanomaterials, and apply them in constructing a near-infrared (NIR) light controlled drug-delivery system for rapid necrosis of bacteria. In this design, the NIR stimuli-responsive functional shell is located on the external tube wall of TiO2 NT; the internal tube wall offers sufficient binding sites for drug loading. Using kanamycin as a model drug, we demonstrate that the reactive oxygen species generated in photocatalysis not only controllably release the loaded drug by scissoring the linked chains, but also effectively compromise bacteria membrane integrity by damaging the cell wall. Benefiting from the damages, antibiotics r

#	Concept	H-Index	Publications	Citations
1	Medicine	3	3	52
2	Engineering	2	2	57
3	Biomedical Engineering	2	2	34
4	Health Sciences	1	1	18
5	Chemical Engineering	1	1	41

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