Polo-like Kinase-1 Regulates Myc Stabilization and Activates a Feedforward Circuit Promoting Tumor Cell Survival

Daibiao Xiao, Yue Ming, Hexiu Su, +7

Molecular Cell

Cancer ResearchSignal TransductionSignaling PathwayCell RegulationMedicine +7

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis

Jue Jiang, Jingchao Wang, Ming Yue, +15

Cancer Cell

Hematological MalignancySignal TransductionDirect PhosphorylationReceptor Tyrosine KinaseMalignant Blood Disorder +8

SHQ1 regulation of RNA splicing is required for T-lymphoblastic leukemia cell survival

Hexiu Su, Juncheng Hu, Liang Huang, +12

Nature Communications

Myc promotes glutaminolysis in human neuroblastoma through direct activation of glutaminase 2

Daibiao Xiao, Ping Ren, Hexiu Su, +5

Oncotarget

Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes

Wei Li, Zhiwu Jiang, Tianzhong Li, +20

Molecular Cancer

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

Ye Qi, Jue Jiang, Guanqun Zhan, +10

Scientific Reports

WEE1 inhibition induces glutamine addiction in T-cell acute lymphoblastic leukemia

Juncheng Hu, Tianci Wang, Jin Xu, +12

Haematologica

Wee1 KinaseHematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood Disorder +13

The NOTCH Ligand JAGGED2 Promotes Pancreatic Cancer Metastasis Independent of NOTCH Signaling Activation

Yufeng Hu, Hexiu Su, Xu Li, +5

Molecular Cancer Therapeutics

Synergistic targeting of CHK1 and mTOR in MYC-driven tumors

Xiaoxue Song, Liyuan Wang, Tianci Wang, +7

Carcinogenesis