A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Weiqi Zhang, Jingyi Li, Keiichiro Suzuki, +31

Science

SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2

Huize Pan, Di Guan, Xiaomeng Liu, +19

Cell Research

SIRT6 deficiency results in developmental retardation in cynomolgus monkeys

Weiqi Zhang, Haifeng Wan, Guihai Feng, +15

Nature

Developmental BiologyGenetic DisorderDevelopmental GeneticsGeneticsMolecular Genetics +3

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

Keiichiro Suzuki, Chang Yu, Jing Qu, +20

Cell stem cell

Induced Pluripotent Stem CellMedicineGeneticsWhole-genome Mutational LoadGenetic Engineering +7

PTEN deficiency reprogrammes human neural stem cells towards a glioblastoma stem cell-like phenotype

Shunlei Duan, Guohong Yuan, Xiaomeng Liu, +22

Nature Communications

Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis

Liping Deng, Ruotong Ren, Zunpeng Liu, +12

Nature Communications

Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis

Xiaoqing Ren, Boqiang Hu, Moshi Song, +13

Cell Reports

Chemical screen identifies a geroprotective role of quercetin in premature aging

Lingling Geng, Zunpeng Liu, Weiqi Zhang, +12

Protein & Cell

Werner SyndromeAgingAnti-agingWs HmscsBiogerontology +17

Modelling Fanconi anemia pathogenesis and therapeutics using integration-free patient-derived iPSCs

Guang Hui Liu, Keiichiro Suzuki, Mo Li, +30

Nature Communications

Systems PharmacologyTranslational MedicineEngineeringHematologyFanconi Anemia Pathogenesis +3

ATF6 safeguards organelle homeostasis and cellular aging in human mesenchymal stem cells

Si Wang, Boqiang Hu, Zhichao Ding, +15

Cell Discovery