Christian Beerli

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

Carolyn A. Foster, Laurence M. Howard, Alain Schweitzer et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 323 citations

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

Daniela Angst, F. Gessier, Philipp Janser et al. · Journal of Medicinal Chemistry · 2020 · 149 citations · Full text

Discovery of 3-(1<i>H</i>-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

Jürgen Wagner, Peter Matt, Richard Sedrani et al. · Journal of Medicinal Chemistry · 2009 · 131 citations · Full text

Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo

Gebhard Thoma, Markus Streiff, Jiří Kovařík et al. · Journal of Medicinal Chemistry · 2008 · 128 citations · Full text

Immunology, Immunologic Mechanism, Pharmacotherapy +17

A Monoselective Sphingosine-1-Phosphate Receptor-1 Agonist Prevents Allograft Rejection in a Stringent Rat Heart Transplantation Model

Shifeng Pan, Yuan Mi, Charles Pally et al. · Chemistry & Biology · 2006 · 125 citations

Heart Failure, Transplantation, Xenotransplantation +7