Christian Beerli

Brain Penetration of the Oral Immunomodulatory Drug FTY720 and Its Phosphorylation in the Central Nervous System during Experimental Autoimmune Encephalomyelitis: Consequences for Mode of Action in Multiple Sclerosis

Carolyn A. Foster, Laurence M. Howard, Alain Schweitzer et al. · Journal of Pharmacology and Experimental Therapeutics · 2007 · 324 citations

Medicine, Neurology, Pharmacology +17

Discovery of LOU064 (Remibrutinib), a Potent and Highly Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase

Daniela Angst, F. Gessier, Philipp Janser et al. · Journal of Medicinal Chemistry · 2020 · 162 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +14

Discovery of 3-(1<i>H</i>-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

Jürgen Wagner, Peter Matt, Richard Sedrani et al. · Journal of Medicinal Chemistry · 2009 · 134 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Orally Bioavailable Isothioureas Block Function of the Chemokine Receptor CXCR4 In Vitro and In Vivo

Gebhard Thoma, Markus Streiff, Jiří Kovařík et al. · Journal of Medicinal Chemistry · 2008 · 129 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Potent and Selective S1P1 Antagonist with Efficacy in Experimental Autoimmune Encephalomyelitis

Jean Quancard, Birgit Bollbuck, Philipp Janser et al. · Chemistry & Biology · 2012 · 128 citations

Life Sciences, Neurology, Neuroscience +10