Biogenic amine depletion causes chronic muscular pain and tactile allodynia accompanied by depression: A putative animal model of fibromyalgia

Yukinori Nagakura, Tomoya Oe, Toshiaki Aoki, +1

Pain

Differential Effects between γ-Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

Yasuyuki Mitani, Junko Yarimizu, Kyoko Saita, +5

Journal of Neuroscience

Evidence for the involvement of GABAA receptor blockade in convulsions induced by cephalosporins

Masahiro Sugimoto, Ichirō Uchida, Takashi Mashimo, +6

Neuropharmacology

NeurophysiologyMedicinePhysiologyNeuropeptide ReceptorNeuropharmacology +6

Neuroprotective Efficacy of the Peroxisome Proliferator-Activated Receptor δ-Selective Agonists in Vitro and in Vivo

Akinori Iwashita, Yuko Muramatsu, Takao Yamazaki, +6

Journal of Pharmacology and Experimental Therapeutics

Rational Approaches to Discovery of Orally Active and Brain-Penetrable Quinazolinone Inhibitors of Poly(ADP-ribose)polymerase

Kouji Hattori, Yoshiyuki Kido, Hirofumi Yamamoto, +11

Journal of Medicinal Chemistry

Drug TargetBioorganic ChemistryOrally ActivePharmacotherapyChemical Biology +16

Amelioration of Neuropathic Pain by Novel Transient Receptor Potential Vanilloid 1 Antagonist AS1928370 in Rats without Hyperthermic Effect

Tomonari Watabiki, Tetsuo Kiso, Takahiro Kuramochi, +6

Journal of Pharmacology and Experimental Therapeutics

Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: A comparison with diazepam and buspirone

Katsuya Harada, Masaki Aota, Tatsuo Inoue, +5

European Journal of Pharmacology

Psychoactive DrugAnxiolytic ActivityPsychiatryMedicinePsychopharmacology +9

A Novel and Potent Poly(ADP-Ribose) Polymerase-1 Inhibitor, FR247304 (5-Chloro-2-[3-(4-phenyl-3,6-dihydro-1(2 H)-pyridinyl)propyl]-4(3 H)-quinazolinone), Attenuates Neuronal Damage in in Vitro and in Vivo Models of Cerebral Ischemia

Akinori Iwashita, Nobuteru Tojo, Shigeru Matsuura, +7

Journal of Pharmacology and Experimental Therapeutics

Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

Junya Ishida, Hirofumi Yamamoto, Yoshiyuki Kido, +10

Bioorganic & Medicinal Chemistry

Molecular DockingSbdd AnalysisMedicinal ChemistryDrug TargetBiochemistry +10

Pharmacological evidence for a correlation between hippocampal CA1 cell damage and hyperlocomotion following global cerebral ischemia in gerbils

Kiyotaka Katsuta, Kazuo Umemura, Noriko Ueyama, +1

European Journal of Pharmacology

NeurophysiologyMedicineNeuropharmacologyBrain InjuryNeuroprotection +11