Screening thep53 status of human cell lines using a yeast functional assay

Liqun Jia, Motonobu Osada, Chikashi Ishioka, +14

Molecular Carcinogenesis

Establishment of a New Extrahepatic Bile Duct Carcinoma Cell Line, TFK-1.

Susumu Saijyo, Toshio Kudo, Masanori Suzuki, +6

The Tohoku Journal of Experimental Medicine

PathologyTumor BiologyTumor MarkersOncologyHepatobiliary Tumor +14

Antitumor activity of interleukin‐21 prepared by novel refolding procedure from inclusion bodies expressed in <i>Escherichia coli</i>

Ryutaro Asano, Toshio Kudo, Koki Makabe, +2

FEBS Letters

Humanization of the Bispecific Epidermal Growth Factor Receptor × CD3 Diabody and Its Efficacy as a Potential Clinical Reagent

Ryutaro Asano, Yukiko Sone, Koki Makabe, +6

Clinical Cancer Research

Highly Effective Recombinant Format of a Humanized IgG-like Bispecific Antibody for Cancer Immunotherapy with Retargeting of Lymphocytes to Tumor Cells

Ryutaro Asano, Yasuhiro Watanabe, Hiroko Kawaguchi, +8

Journal of Biological Chemistry

Immunocytochemical TechniqueImmunologyImmunologic MechanismTumor CellsAntigen Processing +17

MUC1-specific targeting immunotherapy with bispecific antibodies: inhibition of xenografted human bile duct carcinoma growth.

Yu Katayose, Toshio Kudo, Masanori Suzuki, +7

PubMed

ImmunologyImmunotherapyTumor BiologyOncologyGastrointestinal Oncology +14

Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody

Ryutaro Asano, Takashi Kumagai, Keisuke Nagai, +15

Protein Engineering Design and Selection

A highly effective and stable bispecific diabody for cancer immunotherapy: cure of xenografted tumors by bispecific diabody and T-LAK cells

Hiroki Hayashi, Ryutaro Asano, Kouhei Tsumoto, +11

Cancer Immunology Immunotherapy

Tumor ImmunologyCancer ImmunosurveillanceT-lak CellsMedicineImmunology +8

Tumor-directed lymphocyte-activating cytokines: refolding-based preparation of recombinant human interleukin-12 and an antibody variable domain-fused protein by additive-introduced stepwise dialysis

Koki Makabe, Ryutaro Asano, Takahiko Ito, +3

Biochemical and Biophysical Research Communications

Refolding-based PreparationImmunologyTumor-directed Lymphocyte-activating CytokinesImmunologic MechanismImmunomodulation +5

Construction and humanization of a functional bispecific EGFR × CD16 diabody using a refolding system

Ryutaro Asano, Makoto Nakayama, Hiroko Kawaguchi, +8

FEBS Journal

EngineeringMechanical EngineeringImmunologyImmunoeditingImmunotherapeutics +20