Uric Acid Secretion from Adipose Tissue and Its Increase in Obesity

Yu Tsushima, Hitoshi Nishizawa, Yoshihiro Tochino, +11

Journal of Biological Chemistry

Longitudinal analysis of murine steatohepatitis model induced by chronic exposure to high‐fat diet

Makoto Ito, Jun Suzuki, Shigeharu Tsujioka, +8

Hepatology Research

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

Johji Nomura, Nathalie Busso, Annette Ives, +7

Scientific Reports

Activation of sodium-glucose cotransporter 1 ameliorates hyperglycemia by mediating incretin secretion in mice

Ryuichi Moriya, Takashi Shirakura, Junko Itô, +2

American Journal of Physiology-Endocrinology and Metabolism

Glucose AbsorptionGlucose HomeostasisIncretin SecretionInsulin SignalingGastrointestinal Peptide Hormone +17

Xanthine oxidase inhibition attenuates insulin resistance and diet-induced steatohepatitis in mice

Tomoki Nishikawa, Naoto Nagata, Tetsuro Shimakami, +14

Scientific Reports

Xanthine Oxidase Mediates Axonal and Myelin Loss in a Murine Model of Multiple Sclerosis

Josephe A. Honorat, Makoto Kinoshita, Tatsusada Okuno, +8

PLoS ONE

Activity of xanthine oxidase in plasma correlates with indices of insulin resistance and liver dysfunction in patients with type 2 diabetes mellitus and metabolic syndrome: A pilot exploratory study

Sumito Sunagawa, Takashi Shirakura, Noboru Hokama, +13

Journal of Diabetes Investigation

Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats

Takashi Shirakura, Johji Nomura, Chieko Matsui, +3

Naunyn-Schmiedeberg s Archives of Pharmacology

Molecular PharmacologyHypertensionCardiovascular DiseaseMedicineAntihypertensive Therapy +11

NPY Y2 receptor agonist PYY(3-36) inhibits diarrhea by reducing intestinal fluid secretion and slowing colonic transit in mice

Ryuichi Moriya, Takashi Shirakura, Hiroyasu Hirose, +3

Peptides

Intestinal Fluid SecretionMedicinePhysiologyGastroenterologyDigestive Tract +4

Pancreatic polypeptide enhances colonic muscle contraction and fecal output through neuropeptide Y Y4 receptor in mice

Ryuichi Moriya, Toru Fujikawa, Junko Itô, +6

European Journal of Pharmacology

Colonic Muscle ContractionNeuropeptidesMolecular PhysiologyMedicinePhysiology +6