Prostaglandins PGE2 and PGI2 promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation

Anna A. Birukova, Tatiana K. Zagranichnaya, Panfeng Fu, +3

Experimental Cell Research

InflammationSignal TransductionAngiogenesisSignaling PathwayG Protein-coupled Receptor +12

DPP4 inhibition by sitagliptin attenuates LPS-induced lung injury in mice

Takeshi Kawasaki, Weiguo Chen, Yu Maw Htwe, +2

American Journal of Physiology-Lung Cellular and Molecular Physiology

Acute Lung InjuryInflammatory Lung DiseaseLung InflammationImmunologyDpp4 Inhibitor +18

Peroxynitrite Induces Destruction of the Tetrahydrobiopterin and Heme in Endothelial Nitric Oxide Synthase: Transition from Reversible to Irreversible Enzyme Inhibition

Weiguo Chen, Lawrence J. Druhan, Chun‐An Chen, +5

Biochemistry

Peroxynitrite Induces DestructionRedox BiologyOxidative StressInflammationReactive Nitrogen Specie +15

Endothelial cell barrier protection by simvastatin: GTPase regulation and NADPH oxidase inhibition

Weiguo Chen, Srikanth Pendyala, Viswanathan Natarajan, +2

American Journal of Physiology-Lung Cellular and Molecular Physiology

Superoxide GenerationLipid PeroxidationNadph Oxidase InhibitionRedox BiologyOxidative Stress +15

Formation of Protein Tyrosine ortho-Semiquinone Radical and Nitrotyrosine from Cytochrome c-derived Tyrosyl Radical

Yeong-Renn Chen, Chwen Lih Chen, Weiguo Chen, +4

Journal of Biological Chemistry

Functional effect of the R110Q IL13 genetic variant alone and in combination with IL4RA genetic variants

Weiguo Chen, Mark B. Ericksen, Linda Levin, +1

Journal of Allergy and Clinical Immunology

IL-13Rα2 Membrane and Soluble Isoforms Differ in Humans and Mice

Weiguo Chen, Umasundari Sivaprasad, Yasuhiro Tabata, +4

The Journal of Immunology

Il-13rα2 MembraneImmunologyMemil-13ralpha2 TranscriptImmunologic MechanismImmune System +15

Level of Expression of IL-13Rα2 Impacts Receptor Distribution and IL-13 Signaling

Michael Daines, Yasuhiro Tabata, B Walker, +4

The Journal of Immunology

Genomic architecture of asthma differs by sex

Tesfaye B. Mersha, Lisa J. Martin, Jocelyn M. Biagini Myers, +6

Genomics

AsthmaGeneticsSex DifferencesGenetic FoundationGenomics +3

Identification of KIF3A as a Novel Candidate Gene for Childhood Asthma Using RNA Expression and Population Allelic Frequencies Differences

Melinda Butsch Kovacic, Jocelyn M. Biagini Myers, Ning Wang, +25

PLoS ONE