DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development

Masaki Okano, Daphne W. Bell, Daniel A. Haber, +1

Cell

Histone ModificationsChromatinDna Methyltransferases Dnmt3aDevelopmental BiologyEpigenetic Change +11

High-throughput screening using patient-derived tumor xenografts to predict clinical trial drug response

Hui Gao, Joshua M. Korn, Stéphane Ferretti, +61

Nature Medicine

Tumor BiologyRadiologyOncologyCancer DetectionCancer Screening +8

Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting

Masahiro Kaneda, Masaki Okano, Kenichiro Hata, +4

Nature

ChromatinDevelopmental BiologyEssential RoleMedicineGenetics +11

Reversal of Histone Lysine Trimethylation by the JMJD2 Family of Histone Demethylases

Johnathan R. Whetstine, Amanda C. Nottke, Fei Lan, +8

Cell

Histone ModificationsChromatinChromatin StructureBiochemistryChromatin Remodeling +9

Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons

Jian Feng, Yu Zhou, Susan L. Campbell, +5

Nature Neuroscience

ChromatinSynaptic PlasticityMolecular NeuroscienceEpigenetic ChangeGenetics +9

Gene Dosage–Dependent Embryonic Development and Proliferation Defects in Mice Lacking the Transcriptional Integrator p300

Tso-Pang Yao, S. Paul Oh, Miriam Fuchs, +7

Cell

Transcriptional RegulationProliferation DefectsDevelopmental BiologyGeneticsGene Regulation +6

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

Jing Wang, Sarah Hevi, Julia K. Kurash, +10

Nature Genetics

ChromatinChromatin RemodelingEpigenetic ChangeGeneticsDna Methylation +8

De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells

Hong Lei, S. Paul Oh, Masaki Okano, +4

Development

Female infertility in mice lacking connexin 37

Alexander M. Simon, Daniel A. Goodenough, En Li, +1

Nature

InfertilityFertilityFemale InfertilityGynecologyFemale Reproductive System +8

Establishment and Maintenance of Genomic Methylation Patterns in Mouse Embryonic Stem Cells by Dnmt3a and Dnmt3b

Taiping Chen, Yoshihide Ueda, Jonathan Dodge, +2

Molecular and Cellular Biology

Genomic Methylation PatternsEpigenetic ChangeGeneticsDna MethylationEpigenetics +14