A Structure of the Human Apoptosome at 12.8 Å Resolution Provides Insights into This Cell Death Platform

Xinchao Yu, Devrim Acehan, Jean‐François Ménétret, +6

Structure

Human CellApoptosisAutophagyMolecular BiologyCell Death +6

Three-dimensional Structure of a Double Apoptosome Formed by the Drosophila Apaf-1 Related Killer

Xinchao Yu, Lai Wang, Devrim Acehan, +2

Journal of Molecular Biology

ChromatinThree-dimensional StructureGene StructureMolecular BiologyMolecular Genetics +5

Structure of an Apoptosome-Procaspase-9 CARD Complex

Shujun Yuan, Xinchao Yu, Maya Topf, +3

Structure

Protein FunctionNatural SciencesMedicineMolecular BiologyApoptosome-procaspase-9 Card Complex +5

Structural basis for pharmacological modulation of the TRPC6 channel

Yonghong Bai, Xinchao Yu, Hao Chen, +8

eLife

Trpc6 InhibitionCytoskeletonCellular PhysiologyTrpc6 ModulationMolecular Pharmacology +17

A Structure-Based Mechanism for Arf1-Dependent Recruitment of Coatomer to Membranes

Xinchao Yu, Marianna Breitman, Jonathan M. Goldberg

Cell

Membrane StructureProteinlipid InteractionArf1-dependent RecruitmentNatural SciencesMembrane Transport +7

The Holo-Apoptosome: Activation of Procaspase-9 and Interactions with Caspase-3

Shujun Yuan, Xinchao Yu, John M. Asara, +3

Structure

Signal TransductionApoptosisCell DeathCellular BiochemistryMedicine +3

Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition

Ching-Shin Huang, Xinchao Yu, Preston Fordstrom, +7

Science Advances

Structure of the Drosophila Apoptosome at 6.9 Å Resolution

Shujun Yuan, Xinchao Yu, Maya Topf, +4

Structure

Developmental GeneticsGeneticsGene StructureMolecular BiologyMolecular Genetics +3

Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex

Yue Hao, Xinchao Yu, Yonghong Bai, +2

PLoS ONE

Distinct Binding SitesCrystal StructureCryo-em StructureMedicineProtein X-ray Crystallography +9

Enhancing the Prefusion Conformational Stability of SARS-CoV-2 Spike Protein Through Structure-Guided Design

Timothy P. Riley, Hui‐Ting Chou, Ruozhen Hu, +9

Frontiers in Immunology

EngineeringProtein AssemblyViral PathogenesisImmunologyBiomedical Engineering +18