Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial

Gerald S. Falchook, Georgina V. Long, Razelle Kurzrock, +14

The Lancet

Neuro-oncologyUntreated Brain MetastasesMedicineMelanomaPharmacotherapy +5

BRAF Inhibitor Dabrafenib in Patients with Metastatic <i>BRAF</i> -Mutant Thyroid Cancer

Gerald S. Falchook, Michael Millward, David S. Hong, +9

Thyroid

A Phase I/II Trial of Pazopanib in Combination with Lapatinib in Adult Patients with Relapsed Malignant Glioma

David A. Reardon, Morris D. Groves, Patrick Y. Wen, +10

Clinical Cancer Research

Triptolide induces Sertoli cell apoptosis in mice via ROS/JNK-dependent activation of the mitochondrial pathway and inhibition of Nrf2-mediated antioxidant response

Yu Wang, Suhan Guo, Xue‐Jun Shang, +7

Acta Pharmacologica Sinica

InflammationReductive StressMedicineLipid PeroxidationApoptosis +10

Triptolide disrupts fatty acids and peroxisome proliferator-activated receptor (PPAR) levels in male mice testes followed by testicular injury: A GC–MS based metabolomics study

Bo Ma, Huanhuan Qi, Jing Li, +6

Toxicology

Male Mice TestesMetabolic SyndromeAndrologyFatty AcidsTesticular Injury +7

Dairy, Magnesium, and Calcium Intake in Relation to Insulin Sensitivity: Approaches to Modeling a Dose-dependent Association

Bo Ma, Andrew B. Lawson, Angela D. Liese, +2

American Journal of Epidemiology

NutritionDose-dependent AssociationNutritional EpidemiologyMetabolic SyndromeBody Composition +16

Oridonin exerts anticancer effect on osteosarcoma by activating PPAR-γ and inhibiting Nrf2 pathway

Ying Lü, Yang Sun, Jianwei Zhu, +6

Cell Death and Disease

Lignin-Incorporated Nanogel Serving As an Antioxidant Biomaterial for Wound Healing

Jia Xu, Jia Xu, Qianyu Lin, +9

ACS Applied Bio Materials

Corosolic acid, a natural triterpenoid, induces ER stress-dependent apoptosis in human castration resistant prostate cancer cells via activation of IRE-1/JNK, PERK/CHOP and TRIB3

Bo Ma, Hang Zhang, Yu Wang, +6

Journal of Experimental & Clinical Cancer Research

Rational Design of a Two‐Photon Fluorogenic Probe for Visualizing Monoamine Oxidase A Activity in Human Glioma Tissues

Haixiao Fang, Hang Zhang, Lin Li, +11

Angewandte Chemie International Edition