Discovery of <i>N</i>1-(4-((7-Cyclopentyl-6-(dimethylcarbamoyl)-7<i>H</i>-pyrrolo[2,3-<i>d</i>]pyrimidin-2-yl)amino)phenyl)-<i>N</i>8-hydroxyoctanediamide as a Novel Inhibitor Targeting Cyclin-dependent Kinase 4/9 (CDK4/9) and Histone Deacetlyase1 (HDAC1) against Malignant Cancer

Yongtao Li, Xiaohe Luo, Qingxiang Guo, +11

Journal of Medicinal Chemistry

Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling

Zhi Huang, Wei Zhou, Yongtao Li, +14

Theranostics

Global sensitivity analysis of hepatic venous pressure gradient (HVPG) measurement with a stochastic computational model of the hepatic circulation

Tianqi Wang, Fuyou Liang, Zun-Qiang Zhou, +1

Computers in Biology and Medicine

EngineeringHepatologyHepatic CirculationMeasurementStochastic Computational Model +12

Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-κB Ligand (RANKL)—Receptor Activator of Nuclear Factor-κB (RANK) Protein–Protein Interaction by Structure-Based Virtual Screening and Hit Optimization

Min Jiang, Peng Lei, Kai Yang, +12

Journal of Medicinal Chemistry

Drug TargetSclerostinHit IdentificationMolecular BiologyOsteoporosis +17

A computational model of the hepatic circulation applied to analyze the sensitivity of hepatic venous pressure gradient (HVPG) in liver cirrhosis

Tianqi Wang, Fuyou Liang, Zun-Qiang Zhou, +1

Journal of Biomechanics

EngineeringHepatologyHepatic CirculationComputational ModelMedicine +11

Novel dual inhibitors targeting CDK4 and VEGFR2 synergistically suppressed cancer progression and angiogenesis

Zhi Huang, Borui Zhao, Zhongxiang Qin, +8

European Journal of Medicinal Chemistry

AngiogenesisMedicineCancer ProgressionNovel Dual InhibitorsRadiation Oncology +3

Discovery of a highly potent, selective and novel CDK9 inhibitor as an anticancer drug candidate

Yongtao Li, Qingxiang Guo, Chao Zhang, +9

Bioorganic & Medicinal Chemistry Letters

Novel TherapyMedicineNovel Cdk9 InhibitorTumor TargetingAnti-cancer Agent +6

Higher visceral adiposity index was associated with an elevated prevalence of gallstones and an earlier age at first gallstone surgery in US adults: the results are based on a cross-sectional study

Gaopeng Zhang, Junping Yang, Tianqi Wang, +3

Frontiers in Endocrinology

Machine Learning-Based Pulse Wave Analysis for Early Detection of Abdominal Aortic Aneurysms Using In Silico Pulse Waves

Tianqi Wang, Weiwei Jin, Fuyou Liang, +1

Symmetry

Medical MonitoringEngineeringDiagnosisBiomedical Signal AnalysisElectrophysiological Evaluation +22

Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K/Akt/eNOS pathway

Rui Chen, Ting Chen, Tianqi Wang, +5

Journal of Ethnopharmacology

CardiomyopathyCardiovascular DiseaseTongmai Yangxin PillPhysiologyPharmacology +8