Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Li Zhong, Ying Xu, Rengong Zhuo, +20

Nature Communications

Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Qiuyang Zheng, Guilin Li, Shihua Wang, +16

Science Advances

β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Yini Zhao, Qiuyang Zheng, Yujuan Hong, +14

Nature Neuroscience

Neurodegenerative Diseasesβ2-Microglobulin CoaggregatesAlzheimer's DiseaseDisease Model MiceDegenerative Pathology +7

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Yue Gao, Yujuan Hong, Lihong Huang, +22

Cell

β2-Microglobulin FunctionsSynaptic PlasticityMolecular NeuroscienceMedicineSynaptic Transmission +11

Esculin ameliorates cognitive impairment in experimental diabetic nephropathy and induces anti-oxidative stress and anti-inflammatory effects via the MAPK pathway

Yu Song, Xiaochun Wang, Shengkai Qin, +3

Molecular Medicine Reports

ImmunologyRenal InflammationExperimental PharmacologyOxidative StressInflammation +18

RPS23RG1 Is Required for Synaptic Integrity and Rescues Alzheimer’s Disease–Associated Cognitive Deficits

Dongdong Zhao, Jian Meng, Yingjun Zhao, +21

Biological Psychiatry

Synaptic PlasticityNeurodegenerative DiseasesMolecular NeuroscienceAlzheimer's DiseaseSynaptic Neuroscience +10

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Fanwei Zeng, Xuehai Ma, Lin Zhu, +28

PLoS Biology

NeurotransmitterMolecular BiologyNeurochemical BiomarkersNmda Receptor StabilityStructural Plasticity +14

SNX27 Deletion Causes Hydrocephalus by Impairing Ependymal Cell Differentiation and Ciliogenesis

Xin Wang, Ying Zhou, Jian Wang, +10

Journal of Neuroscience

Synaptic Adhesion Molecule Pcdh-γC5 Mediates Synaptic Dysfunction in Alzheimer's Disease

Yanfang Li, Zhicai Chen, Yue Gao, +6

Journal of Neuroscience

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Haibin Zhang, Qiuyang Zheng, Tiantian Guo, +20

Molecular Psychiatry

NeuroregenerationNeurophysiologyMetabolic ReprogrammingNeurological FunctionNeuronal Dysfunction +8