The crystal structures of severe acute respiratory syndrome virus main protease and its complex with an inhibitor

Haitao Yang, Maojun Yang, Yi Ding, +12

Proceedings of the National Academy of Sciences

Viral ReplicationSars VirusProtein AssemblyBiomolecular Structure PredictionSars-cov Main Protease +15

In vivo structural characterization of the SARS-CoV-2 RNA genome identifies host proteins vulnerable to repurposed drugs

Lei Sun, Pan Li, Xiaohui Ju, +12

Cell

EngineeringRna Structure PredictionRna BiologyMolecular BiologyViral Structural Protein +2

Crystal Structure of Methyl Parathion Hydrolase from Pseudomonas sp. WBC-3

Yan-Jie Dong, Mark Bartlam, Lei Sun, +5

Journal of Molecular Biology

Crystal StructureBiochemistryProtein X-ray CrystallographyStructure-function Enzyme KineticsMicrobiology +2

Integrative Analysis of Zika Virus Genome RNA Structure Reveals Critical Determinants of Viral Infectivity

Pan Li, Yifan Wei, Miao Mei, +11

Cell Host & Microbe

Virus StructureViral ReplicationMolecular VirologyGeneticsPathogenesis +6

Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures

Lei Sun, Kui Xu, Wenze Huang, +5

Cell Research

Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2

Shaojun Zhang, Wenze Huang, Lili Ren, +8

Cell Research

Application of γ-aminobutyric acid induces disease resistance in apples through regulation of polyamine metabolism, GABA shunt and reactive oxygen species metabolism

Jie Zhu, Canying Li, Lei Sun, +4

Scientia Horticulturae

BiochemistryGaba ShuntPhysiologyHost Resistanceγ-Aminobutyric Acid Induces +7

Exogenous γ-aminobutyric acid maintains fruit quality of apples through regulation of ethylene anabolism and polyamine metabolism

Canying Li, Jie Zhu, Lei Sun, +4

Plant Physiology and Biochemistry

Food ChemistryEngineeringBiochemistryFood QualityBiotechnology +8

Influences of postharvest ATP treatment on storage quality and enzyme activity in sucrose metabolism of Malus domestica

Lei Sun, Canying Li, Jie Zhu, +3

Plant Physiology and Biochemistry

Energy MetabolismIn Vitro FermentationBiochemistryBioenergeticsMedicine +8

Crystal structure of the pyridoxal‐5′‐phosphate‐dependent serine dehydratase from human liver

Lei Sun, Mark Bartlam, Yiwei Liu, +2

Protein Science

Crystal StructureAldehyde DehydrogenaseAldo-keto ReductaseBiochemistryNatural Sciences +10