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Gut Microbes

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Role of endogenous thrombin in tumor implantation, seeding, and spontaneous metastasis

Liang Hu, Merlin Lee, Wendy Campbell, +2

Blood

Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies

Qian Liu, Jing Zhang, Chenchen Guo, +27

Cell

Tumor BiologyMedicineBiological InsightsCancer GenomicsBronchial Neoplasm +8

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

Yao-Qi Huang, Jianjun Li, Liang Hu, +2

Blood

Thrombin Up-regulates Cathepsin D which Enhances Angiogenesis, Growth, and Metastasis

Liang Hu, Jennifer Roth, Peter C. Brooks, +2

Cancer Research

Cullin5 deficiency promotes small-cell lung cancer metastasis by stabilizing integrin β1

Gaoxiang Zhao, Liyan Gong, Dan Su, +20

Journal of Clinical Investigation

Integrin β1ImmunologyCell DeathCancer BiologyTumor Biology +16

Growth-Regulated Oncogene Is Pivotal in Thrombin-Induced Angiogenesis

Maresa Caunt, Liang Hu, Thomas T. Tang, +3

Cancer Research

Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer

Chenchen Guo, Ruijie Wan, Yayi He, +16

Nature Cancer

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Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer

Xinyuan Tong, Ayushi S. Patel, Eejung Kim, +37

Cancer Cell

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

Yuetong Wang, Jian Zhang, Shengxiang Ren, +24

Cell Reports