A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer's disease pathology in mice

Shuyu Liu, Fujiko Ando, Yu Fujita, +11

Journal of Biological Chemistry

Alzheimer's DiseaseMedicineDementiaAngiotensin-converting EnzymeDisease Pathology +7

Aβ43 Is the Earliest-Depositing Aβ Species in APP Transgenic Mouse Brain and Is Converted to Aβ41 by Two Active Domains of ACE

Kun Zou, Junjun Liu, Atsushi Watanabe, +8

American Journal Of Pathology

Neurodegenerative DiseasesMolecular NeuroscienceNeurobiology Of DiseaseDevelopmental BiologyCellular Neuroscience +12

MiR-138-5p Targets MACF1 to Aggravate Aging-related Bone Loss

Zhihao Chen, Ying Huai, Gaoyang Chen, +18

International Journal of Biological Sciences

Angiotensin type 1a receptor deficiency decreases amyloid β-protein generation and ameliorates brain amyloid pathology

Junjun Liu, Shuyu Liu, Yukino Matsumoto, +8

Scientific Reports

MACF1 promotes osteoblast differentiation by sequestering repressors in cytoplasm

Lifang Hu, Chong Yin, Dong Chen, +9

Cell Death and Differentiation

Developmental BiologyBone BiologyCell DivisionOsteogenesisBone Homeostasis +3

Effects of per- and poly-fluorinated alkyl substances on pancreatic and endocrine differentiation of human pluripotent stem cells

Shuyu Liu, Renjun Yang, Nuoya Yin, +1

Chemosphere

Induced Pluripotent Stem CellDevelopmental BiologyMedicineStem Cell ToxicologyAdult Stem Cell +6

The Ubiquitin Ligase Synoviolin Up-regulates Amyloid β Production by Targeting a Negative Regulator of γ-Secretase, Rer1, for Degradation

Chiaki Tanabe, Tomoji Maeda, Kun Zou, +4

Journal of Biological Chemistry

Protein FunctionNegative RegulatorProtein FoldingMedicineNatural Sciences +8

Differential effects of angiotensin II receptor blockers on Aβ generation

Junjun Liu, Shuyu Liu, Chiaki Tanabe, +3

Neuroscience Letters

Molecular PharmacologyAβ GenerationSodium HomeostasisMedicineVascular Pharmacology +4

miR-138–5p negatively regulates osteoblast differentiation through inhibiting β-catenin under simulated microgravity in MC3T3-E1 cells

Zhihao Chen, Yan Zhang, Fan Zhao, +10

Acta Astronautica

MechanobiologyMc3t3-e1 CellsDevelopmental BiologyOsteoblast DifferentiationBone Homeostasis +6

Ellagic acid inhibits CDK12 to increase osteoblast differentiation and alleviate osteoporosis in hindlimb-unloaded and ovariectomized mice

Zixiang Wu, Lifang Hu, Kang Ru, +8

Phytomedicine