Design, synthesis, biological evaluation, and molecular modeling studies of quinoline-ferulic acid hybrids as cholinesterase inhibitors

Jun Mo, Hongyu Yang, Tingkai Chen, +9

Bioorganic Chemistry

Combinatorial ChemistryQuinoline-ferulic Acid HybridsCholinesterase InhibitorsBiochemistryNatural Sciences +8

<i>N</i>-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer’s Disease

Chenxi Du, Lei Wang, Qianwen Guan, +7

Journal of Medicinal Chemistry

p62/SQSTM1, a Central but Unexploited Target: Advances in Its Physiological/Pathogenic Functions and Small Molecular Modulators

Ying Chen, Qi Li, Qihang Li, +7

Journal of Medicinal Chemistry

Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation

Xin Lü, Hongyu Yang, Qihang Li, +7

Bioorganic Chemistry

Medicinal ChemistryDrug TargetSelective ButyrylcholinesteraseBiochemistryMedicine +10

Design, Synthesis, and Evaluation of Acetylcholinesterase and Butyrylcholinesterase Dual-Target Inhibitors against Alzheimer’s Diseases

Yan Guo, Hongyu Yang, Zhongwei Huang, +7

Molecules

Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer’s disease

Xueyang Jiang, Yang Wang, Chang Liu, +10

Bioorganic & Medicinal Chemistry

Neurodegenerative DiseasesAlzheimer's DiseasePotential Therapeutic AgentMedicineNeuropharmacology +9

Small molecule KDM4s inhibitors as anti-cancer agents

Hongzhi Lin, Qihang Li, Qi Li, +8

Journal of Enzyme Inhibition and Medicinal Chemistry

Histone ModificationsKdm4s InhibitorsEpigenetic ChangeMolecular BiologyHistone Demethylases +17

Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease

Yuanyuan Wang, Baichen Xiong, Hongzhi Lin, +11

European Journal of Medicinal Chemistry

Natural Product SynthesisAlzheimer's DiseaseBiochemistryFused HybridsMedicine +7

Discovery, molecular dynamic simulation and biological evaluation of structurally diverse cholinesterase inhibitors with new scaffold through shape-based pharmacophore virtual screening

Hongyu Yang, Chenxi Du, Qihang Li, +7

Bioorganic Chemistry

Diverse Cholinesterase InhibitorsMedicinal ChemistryVirtual ScreeningDrug TargetBiochemistry +10

Computational design of binder as the LC3-p62 protein‐protein interaction

Weiping Lyu, Qihang Li, Yingming Wang, +6

Bioorganic Chemistry

Protein ModelingMolecular ModelingLc3-p62 Protein‐protein InteractionMolecular Biology