Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

Hiroyuki Nakayama, Xiongwen Chen, Christopher Baines, +9

Journal of Clinical Investigation

Ca²⁺Influx–Induced Sarcoplasmic Reticulum Ca²⁺Overload Causes Mitochondrial-Dependent Apoptosis in Ventricular Myocytes

Xiongwen Chen, Xiaoying Zhang, Hajime Kubo, +7

Circulation Research

Cardiotoxic and Cardioprotective Features of Chronic β-Adrenergic Signaling

Xiaoying Zhang, Christopher W. Szeto, Erhe Gao, +16

Circulation Research

Adolescent Feline Heart Contains a Population of Small, Proliferative Ventricular Myocytes With Immature Physiological Properties

Xiongwen Chen, Rachel Wilson, Hajime Kubo, +14

Circulation Research

Cardiac MuscleHeart FailureTelomerase ActivityAdult Stem CellCardiac Progenitor Cells +15

Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy

Xiongwen Chen, Hiroyuki Nakayama, Xiaoying Zhang, +11

Journal of Molecular and Cellular Cardiology

Cardiac MuscleCardiomyopathyHeart FailureSignal TransductionMolecular Physiology +13

Overexpression of junctophilin-2 does not enhance baseline function but attenuates heart failure development after cardiac stress

Ang Guo, Xiaoying Zhang, Venkat Iyer, +6

Proceedings of the National Academy of Sciences

Phosphodiesterases coordinate cAMP propagation induced by two stimulatory G protein-coupled receptors in hearts

Shubai Liu, Ying Li, Sung‐Jin Kim, +8

Proceedings of the National Academy of Sciences

Cardiac MuscleHeart FailureCellular PhysiologyPka ActivitiesInflammation +16

The aggregate index of systemic inflammation (AISI): a novel predictor for hypertension

Jiaming Xiu, Xueqin Lin, Qiansheng Chen, +12

Frontiers in Cardiovascular Medicine

MicroRNA-223 Attenuates Hypoxia-induced Vascular Remodeling by Targeting RhoB/MLC2 in Pulmonary Arterial Smooth Muscle Cells

Yan Zeng, Xiaoying Zhang, Kang Kang, +13

Scientific Reports

Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice

Tongtong Cao, Daniela Liccardo, Ryan LaCanna, +7

Frontiers in Cell and Developmental Biology

Cell Cycle ActivityCell CycleMetabolic RemodelingOxidative StressMetabolic Syndrome +16