MTDH Activation by 8q22 Genomic Gain Promotes Chemoresistance and Metastasis of Poor-Prognosis Breast Cancer

Guohong Hu, Robert Chong, Qifeng Yang, +6

Cancer Cell

Mtdh ActivationPoor-prognosis Breast CancerBreast OncologyMedicineCancer Genomics +6

Energetics and dynamics of SNAREpin folding across lipid bilayers

Feng Li, Frédéric Pincet, Éric Perez, +4

Nature Structural & Molecular Biology

Proteinlipid InteractionProtein FoldingLipid MovementMedicineBiophysics +1

A Study of Polyelectrolyte Brushes Formed from Adsorption of Amphiphilic Diblock Copolymers Using the Surface Forces Apparatus

Marc Balastre, Feng Li, Phillip Schorr, +3

Macromolecules

EngineeringSoft MatterPolymersSurface Forces ApparatusPolyelectrolyte Brushes Formed +16

Complexin cross-links prefusion SNAREs into a zigzag array

Daniel Kümmel, Shyam S. Krishnakumar, Daniel T Radoff, +5

Nature Structural & Molecular Biology

Cross-linkMedicineZigzag ArrayMolecular DockingMulti-protein Assembly +1

A conformational switch in complexin is required for synaptotagmin to trigger synaptic fusion

Shyam S. Krishnakumar, Daniel T Radoff, Daniel Kümmel, +8

Nature Structural & Molecular Biology

Synaptic PlasticitySignal TransductionProtein FoldingMolecular BiologyConformational Switch +5

Amplified Detection of T4 Polynucleotide Kinase Activity by the Coupled λ Exonuclease Cleavage Reaction and Catalytic Assembly of Bimolecular Beacons

Ting Hou, Xiuzhong Wang, Xiaojuan Liu, +3

Analytical Chemistry

EngineeringMolecular BiologyChemical BiologyNucleic Acid BiomarkersNucleic Acid Chemistry +15

Gene Silencing Activity of siRNAs with a Ribo-difluorotoluyl Nucleotide

Jie Xia, Anne M. Noronha, Ivanka Toudjarska, +7

ACS Chemical Biology

Complexin activates and clamps SNAREpins by a common mechanism involving an intermediate energetic state

Feng Li, Frédéric Pincet, Éric Perez, +3

Nature Structural & Molecular Biology

Molecular PhysiologySignal TransductionNatural SciencesMolecular BiologyComplexin Activates +10

Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo

Richard W. Cho, Daniel Kümmel, Feng Li, +4

Proceedings of the National Academy of Sciences

A Half-Zippered SNARE Complex Represents a Functional Intermediate in Membrane Fusion

Feng Li, Daniel Kümmel, Jeff Coleman, +3

Journal of the American Chemical Society

Half-zippered Snare ComplexMembrane StructureProtein AssemblyMolecular BiologyAssembled Snare Complex +16