Metabolic regulation of homologous recombination repair by MRE11 lactylation

Yuping Chen, Jinhuan Wu, Linhui Zhai, +24

Cell

Metabolic RegulationGenome InstabilityMedicineMolecular Biology

Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome.

Rui Li, Jonathan D. Knight, G L Bream, +2

Genes & Development

GeneticsMolecular BiologyMolecular GeneticsTranscriptional RegulationGene Structure +17

Selenium detoxification is required for cancer-cell survival

Anne E. Carlisle, Namgyu Lee, Asia N. Matthew-Onabanjo, +12

Nature Metabolism

Selenium DetoxificationSelenium DeficiencyMedicineOncologyRadiation Oncology +3

Consequences of aneuploidy in human fibroblasts with trisomy 21

Sunyoung Hwang, Paola Cavaliere, Rui Li, +3

Proceedings of the National Academy of Sciences

Down SyndromeChromatinGenome InstabilityDevelopmental BiologyCell Division +13

Panax ginseng polysaccharide suppresses metastasis via modulating Twist expression in gastric cancer

Jian‐Ping Cai, Yangjiazi Wu, Cong Li, +5

International Journal of Biological Macromolecules

Twist ExpressionPancreatic CancerChemoprevention StrategyPanax Ginseng PolysaccharideMedicine +8

Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cells

Mihir B. Doshi, Namgyu Lee, Tenzin Tseyang, +12

Nature

OncologySugar Nucleotide ClearanceMedicineOncogenic AgentMolecular Biology +6

Deconvolution of single-cell multi-omics layers reveals regulatory heterogeneity

Longqi Liu, Chuanyu Liu, Andrés Quintero, +34

MultiomicsTranscriptomics TechnologyChromatin AccessibilityCellular PhysiologyTranscriptional Regulation +22

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

Mengdie Wang, Christi A Wisniewski, Choua Xiong, +13

Science Translational Medicine

Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration

Chujiao Lin, Qiyuan Yang, Dongsheng Guo, +17

Nature Communications

OsteoporosisRedox BiologyOrthopaedic SurgeryOxidative StressSkeletal Progenitor Cells +15

Selenium supplementation of lung epithelial cells enhances nuclear factor E2-related factor 2 (Nrf2) activation following thioredoxin reductase inhibition

Rachael Tindell, Stephanie Wall, Qian Li, +4

Redox Biology