Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

Luigi Warren, Philip D. Manos, Tim Ahfeldt, +13

Cell stem cell

Synthetic Modified MrnaInduced Pluripotent Stem CellEngineeringDirected DifferentiationCell Reprogramming +12

Mutations of the VHL tumour suppressor gene in renal carcinoma

James R. Gnarra, Kálmán Tory, Y Weng, +21

Nature Genetics

UrologyGenitourinary CancerKidney ResearchRenal PathologyPathology +6

Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip

Hyun Jung Kim, Hu Li, James J. Collins, +1

Proceedings of the National Academy of Sciences

Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids

Magdalena Kasendra, Alessio Tovaglieri, Alexandra Sontheimer-Phelps, +10

Scientific Reports

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

Kitai Kim, Rui Zhao, Akiko Doi, +11

Nature Biotechnology

Induced Pluripotent Stem CellDonor Cell TypeMedicineGeneticsInduced Pluripotent Stem Cells +9

CellNet: Network Biology Applied to Stem Cell Engineering

Patrick Cahan, Hu Li, Samantha A. Morris, +3

Cell

Stem Cell BiologyHuman CellEngineeringMedicineStem Cell Engineering +7

The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity

Wenzhang Wang, Luwen Wang, Junjie Lu, +12

Nature Medicine

Tdp-43 Mitochondrial LocalizationMitochondrial FunctionNeurophysiologyCell DeathNeuropharmacology +8

Deconstructing transcriptional heterogeneity in pluripotent stem cells

Roshan Kumar, Patrick Cahan, Alex K. Shalek, +11

Nature

LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency

Jin Zhang, Sutheera Ratanasirintrawoot, Sriram Chandrasekaran, +23

Cell stem cell

Induced Pluripotent Stem CellDevelopmental BiologyMedicinePrimed PluripotencyStem Cell Research +5

Interaction of tau with the RNA-Binding Protein TIA1 Regulates tau Pathophysiology and Toxicity

Tara Vanderweyde, Daniel J. Apicco, Katherine Youmans-Kidder, +13

Cell Reports