Molecular Structure of the Human CFTR Ion Channel

Fangyu Liu, Zhe Zhang, László Csanády, +2

Cell

ChannelopathiesSignal TransductionMolecular PhysiologyMembrane TransportPhysiology +4

Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator

Zhe Zhang, Jue Chen

Cell

Molecular PhysiologyNatural SciencesMembrane TransportAtomic StructureMolecular Biology +6

Molecular structure of the ATP-bound, phosphorylated human CFTR

Zhe Zhang, Fangyu Liu, Jue Chen

Proceedings of the National Academy of Sciences

Protein FunctionMolecular PhysiologySignal TransductionBiochemistryCell Signaling +13

Conformational Changes of CFTR upon Phosphorylation and ATP Binding

Zhe Zhang, Fangyu Liu, Jue Chen

Cell

Proteinlipid InteractionSignal TransductionMolecular PhysiologyBiochemistryNatural Sciences +6

Structural identification of a hotspot on CFTR for potentiation

Fangyu Liu, Zhe Zhang, Anat Levit, +4

Science

Molecular PharmacologyProteinlipid InteractionEngineeringBiochemistryProtein Assembly +13

The NAD+-mediated self-inhibition mechanism of pro-neurodegenerative SARM1

Yuefeng Jiang, Tingting Liu, Chia‐Hsueh Lee, +3

Nature

Neurodegenerative DiseasesNad+-mediated Self-inhibition MechanismSignal TransductionNeuroprotectionNeuroscience +3

Human Airway Epithelial Cells Sense<i>Pseudomonas aeruginosa</i>Infection via Recognition of Flagellin by Toll-Like Receptor 5

Zhe Zhang, Jean‐Pierre Louboutin, Daniel J. Weiner, +2

Infection and Immunity

Microbial PathogensLung InflammationToll-like Receptor 5ImmunologyInnate Immune System +18

Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

Zhe Zhang, Balázs Tóth, András Szöllősi, +2

eLife

Protein SecretionHuman Trpm2Molecular RegulationMolecular BiologyCytoskeleton +16

Structure and dynamics of the EGFR/HER2 heterodimer

Xue Bai, Pengyu Sun, Xinghao Wang, +9

Cell Discovery

Crystal StructureHeterodimer AssemblyMolecular BiologyTumor BiologySpectra-structure Correlation +14

Structural insights into the regulation of human serine palmitoyltransferase complexes

Yingdi Wang, Yiming Niu, Zhe Zhang, +9

Nature Structural & Molecular Biology

Protein FunctionProtein ExpressionBiochemistryNatural SciencesMolecular Biology +4