Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury

Jing Ji, Anthony E. Kline, Andrew A. Amoscato, +15

Nature Neuroscience

OxysterolMitochondrial FunctionBiochemistryAtherosclerosisMedicine +10

Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke

Chong Li, Guangchi Sun, Binglin Chen, +12

Pharmacological Research

Cerebral Vascular RegulationIschemic StrokeMedicineCerebral Ischemia-induced FerroptosisCerebrovascular Disease +9

Prokineticin-2 prevents neuronal cell deaths in a model of traumatic brain injury

Zhongyuan Bao, Yinlong Liu, Binglin Chen, +15

Nature Communications

Cardiolipin-Dependent Mitophagy Guides Outcome after Traumatic Brain Injury

Honglu Chao, Chao Lin, Qiang Zuo, +13

Journal of Neuroscience

Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1

Zong Miao, Wei Tian, Yangfan Ye, +10

Cell Death and Disease

Lipid PeroxidationCell DeathCancer BiologyGliomaRedox Biology +22

Modeling Down Syndrome with Patient iPSCs Reveals Cellular and Migration Deficits of GABAergic Neurons

Hai-Qin Huo, Zhuang-Yin Qu, Yuan Fang, +8

Stem Cell Reports

Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury

Chao Lin, Honglu Chao, Zheng Li, +9

Experimental Neurology

InflammationTraumatic Brain InjuryOmega-3 Fatty AcidMedicineBrain-immune Interaction +12

Smoothened Promotes Glioblastoma Radiation Resistance Via Activating USP3-Mediated Claspin Deubiquitination

Yiming Tu, Zhenyao Chen, Pengzhan Zhao, +9

Clinical Cancer Research

MEF2C silencing downregulates NF2 and E-cadherin and enhances Erastin-induced ferroptosis in meningioma

Zhongyuan Bao, Lingyang Hua, Yangfan Ye, +6

Neuro-Oncology

Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis

Zhongyuan Bao, Liang Fan, Lin Zhao, +8

Frontiers in Molecular Neuroscience

Traumatic Brain InjuryApoptosisImmunologyImmune RegulationCell Death +20