23:T551,Growth differentiation factor 11 (GDF11) is an important circulating factor that regulates aging. However, the role of GDF11 in bone metabolism remains unclear. The present study was undertaken to investigate the relationship between serum GDF11 level, bone mass, and bone turnover markers in postmenopausal Chinese women. Serum GDF11 level, bone turnover biochemical markers, and bone mineral density (BMD) were determined in 169 postmenopausal Chinese women (47-78 years old). GDF11 serum levels increased with aging. There were negative correlations between GDF11 and BMD at the various skeletal sites. After adjusting for age and body mass index (BMI), the correlations remained statistically significant. In the multiple linear stepwise regression analysis, age or years since menopause, BMI, GDF11, and estradiol were independent predictors of BMD. A significant negative correlation between GDF11 and bone alkaline phosphatase (BAP) was identified and remained significant after adjusting for age and BMI. No significant correlation was noted between cross-linked N-telopeptides of type I collagen (NTX) and GDF11. In conclusion, GDF11 is an independent negative predictor of BMD and correlates with a biomarker of bone formation, BAP, in postmenopausal Chinese women. GDF11 potentially exerts a negative effect on bone mass by regulating bone formation.24:T449,Ziziphus jujuba Mill is the dried ripe fruit of the Rhamnaceae family; it is widely distributed in Shandong, Henan, Liaoning, and other places in China. In folk medicine, it was used to restore vital energy, as a blood tonic, and for the treatment of spleen deficiency. To date, a complete investigation of the compounds of Z. jujuba has rarely been performed. Therefore, a reliable strategy based on UHPLC-Q-Exactive Orbitrap MS, combined with trace data acquisition mode (parallel reaction monitoring scanning, PRM) and multiple data processing methods, is necessary for the characterization of compounds in the Z. jujuba. Ultimately, 295 compounds, including 69 flavonoids, 60 alkaloids, 82 phenylpropanoids, 52 organic acids, and 32 other components, were identified in the Z. jujuba; of these, 270 have been reported in Z. jujuba for the first time. This study provides deep insights into the chemistry of Z. jujuba and could be useful for further studies aimed at identifying the factors contributing to the health benefits attributed to this fruit.25:T505,In this paper, we show a fast and accurate numerical method for simulating the microwave heating of moving objects, which is still a challenge because of its complicated mathematical model simultaneously coupling electromagnetic field, thermal field, and temperature-dependent moving objects. By contrast with most discrete methods whose dielectric parameters of the heated samples are updated only when they move to a new position or even turn a circle, in our simulations a real-time procedure is added to renew the parameters during the whole heating process. Furthermore, to avoid the mesh-mismatch induced by remeshing the moving objects, we move the cavity instead of samples. To verify the efficiency and accuracy, we compared our method with the arbitrary Lagrangian–Eulerian method, one of the most accurate methods for computing this process until now. For the same computation model, our method helps in decreasing the computing time by about 90% with almost the same accuracy. Moreover, the influence of the rotational speed on the microwave heating is systematically investigated by using this method. The results show the widely used speed in domestic microwave ovens, 5 rpm, is indeed a good choice for improving the temperature uniformity with high energy efficiency.

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3	Law	1	1	26
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