Potent HIV fusion inhibitors against Enfuvirtide-resistant HIV-1 strains

Yuxian He, Jianwei Cheng, Hong Lü, +6

Proceedings of the National Academy of Sciences

Medicinal ChemistryMedicineImmunologyAntiviral ResponseAntiviral Drug Development +12

Gene Expression Variability within and between Human Populations and Implications toward Disease Susceptibility

Jingjing Li, Yu Liu, Tae‐Hyung Kim, +2

PLoS Computational Biology

Disease SusceptibilityPhenotypic VariationSystems BiologyGene Expression LevelGenetic Determinant +13

Identification of a Critical Motif for the Human Immunodeficiency Virus Type 1 (HIV-1) gp41 Core Structure: Implications for Designing Novel Anti-HIV Fusion Inhibitors

Yuxian He, Jianwei Cheng, Jingjing Li, +5

Journal of Virology

Molecular BiologyAntiviral DrugViral Structural ProteinChemical BiologyCritical Motif +17

Conserved Salt Bridge between the N- and C-Terminal Heptad Repeat Regions of the Human Immunodeficiency Virus Type 1 gp41 Core Structure Is Critical for Virus Entry and Inhibition

Yuxian He, Shuwen Liu, Jingjing Li, +5

Journal of Virology

Viral ReplicationProtein AssemblyVirus EntryImmunologyMolecular Biology +15

Tandem bispecific neutralizing antibody eliminates HIV-1 infection in humanized mice

Xilin Wu, Jia Guo, Mengyue Niu, +17

Journal of Clinical Investigation

Combination Antiretroviral TherapyImmunologyImmunodominanceImmunotherapeuticsAntiviral Drug +15

HIV-1 Envelope Glycoprotein Variable Loops Are Indispensable for Envelope Structural Integrity and Virus Entry

Tingting Yuan, Jingjing Li, Mei-Yun Zhang

PLoS ONE

Identification and Characterization of a Broadly Cross-Reactive HIV-1 Human Monoclonal Antibody That Binds to Both gp120 and gp41

Mei-Yun Zhang, Tingting Yuan, Jingjing Li, +11

PLoS ONE

MedicineHuman RetrovirusImmunologyCd4 Binding SiteImmunodominance +11

Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection

Allen Ka Loon Cheung, Hauyee Kwok, Yiru Huang, +20

Nature Microbiology

InflammationInnate Mucosal DamageMucosal ImmunologyAdaptive Immune SystemHuman Retrovirus +12

Reconstitution and characterization of antibody repertoires of HIV-1-infected “elite neutralizers”

Zehua Sun, Jingjing Li, Xintao Hu, +2

Antiviral Research

Antibody RepertoiresHuman RetrovirusImmunologyAntiviral ResponseVirology +6

A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins

Tingting Yuan, Jingjing Li, Mei-Yun Zhang

mAbs

ImmunologyMolecular BiologyViral Structural ProteinImmunotherapyHuman Retrovirus +15