Jie Chen

Metformin extends C. elegans lifespan through lysosomal pathway

Jie Chen, Yuhui Ou, Yi Li et al. · eLife · 2017 · 203 citations · Full text

SAR1B senses leucine levels to regulate mTORC1 signalling

Jie Chen, Yuhui Ou, Rong Luo et al. · Nature · 2021 · 187 citations

Signal Transduction, Molecular Physiology, G Protein-coupled Receptor +5

KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing

Jie Chen, Yuhui Ou, Yanyan Yang et al. · Nature · 2018 · 125 citations

Tumor Biology, Signal Transduction, Signaling Pathway +9

Multiple sequence alignment-based RNA language model and its application to structural inference

Yikun Zhang, Mei Lang, Jiuhong Jiang et al. · Nucleic Acids Research · 2023 · 91 citations · Full text

Engineering, Genetics, Molecular Biology +19

E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

Dong Wang, Chenchen Xu, Wenyu Yang et al. · Molecular Cell · 2022 · 75 citations

Cancer Research, Signaling Pathway, Medicine +11