Structural basis of second-generation HIV integrase inhibitor action and viral resistance

Nicola Cook, Wen Li, Dénes Berta, +7

Science

ImmunologyMolecular BiologyAntiviral DrugDrug ResistanceEnzyme Active Site +18

Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A

Tao Ni, S. Gerard, Gongpu Zhao, +10

Nature Structural & Molecular Biology

Virus StructureProtein FoldingMedicineMolecular BiologyCyclophilin A +6

CPSF6-Dependent Targeting of Speckle-Associated Domains Distinguishes Primate from Nonprimate Lentiviral Integration

Wen Li, Parmit K. Singh, Gregory A. Sowd, +11

mBio

Permeability of the HIV-1 capsid to metabolites modulates viral DNA synthesis

Chaoyi Xu, D Fischer, Sanela Rankovic, +11

PLoS Biology

Integrase-RNA interactions underscore the critical role of integrase in HIV-1 virion morphogenesis

Jennifer L. Elliott, Jenna E. Eschbach, Pratibha C. Koneru, +7

eLife

Viral ReplicationImmunologyMolecular BiologyHuman RetrovirusCritical Role +16

Cotton (Gossypium hirsutum) JAZ3 and SLR1 function in jasmonate and gibberellin mediated epidermal cell differentiation and elongation

Xiao-Cong Xia, Qianqian Hu, Wen Li, +6

Plant Cell Tissue and Organ Culture (PCTOC)

Plant Molecular BiologyPlant BiologyDevelopmental BiologyHealth SciencesCell Division +11

rigrag: high-resolution mapping of genic targeting preferences during HIV-1 integration <i>in vitro</i> and <i>in vivo</i>

Gregory J. Bedwell, Sooin Jang, Wen Li, +2

Nucleic Acids Research

EngineeringImmunodeficienciesImmunologyImmunodominanceImmunotherapy +17

Dominant Negative MA-CA Fusion Protein Is Incorporated into HIV-1 Cores and Inhibits Nuclear Entry of Viral Preintegration Complexes

Jordan Anderson-Daniels, Parmit K. Singh, Gregory A. Sowd, +3

Journal of Virology

Multivalent interactions essential for lentiviral integrase function

Allison Ballandras-Colas, Vidya Chivukula, Dominika T. Gruszka, +17

Nature Communications

Capsid Lattice Destabilization Leads to Premature Loss of the Viral Genome and Integrase Enzyme during HIV-1 Infection

Jenna E. Eschbach, Jennifer L. Elliott, Wen Li, +7

Journal of Virology