Kris Jacobs

Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia

Kim De Keersmaecker, Zeynep Kalender Atak, Ning Li et al. · Nature Genetics · 2012 · 432 citations · Full text

Life Sciences, Genetics, Molecular Genetics +14

JAK3 mutants transform hematopoietic cells through JAK1 activation, causing T-cell acute lymphoblastic leukemia in a mouse model

Sandrine Degryse, Charles E. de Bock, Luk Cox et al. · Blood · 2014 · 144 citations · Full text

Medicine, Genetics, Hematology +11

Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic leukemia

Sandrine Degryse, Charles E. de Bock, Sofie Demeyer et al. · Leukemia · 2017 · 88 citations · Full text

Life Sciences, Cell Biology, Oncology +15

Suz12 inactivation cooperates with JAK3 mutant signaling in the development of T-cell acute lymphoblastic leukemia

Michaël Broux, Cristina Prieto, Sofie Demeyer et al. · Blood · 2019 · 63 citations · Full text

Medicine, Genetics, Molecular Genetics +13

Mutant JAK3 signaling is increased by loss of wild-type JAK3 or by acquisition of secondary JAK3 mutations in T-ALL

Sandrine Degryse, Simon Bornschein, Charles E. de Bock et al. · Blood · 2017 · 37 citations · Full text

Life Sciences, Genetics, Molecular Biology +8