Toward Highly Potent Cancer Agents by Modulating the C-2 Group of the Arylthioindole Class of Tubulin Polymerization Inhibitors

Giuseppe La Regina, Ruoli Bai, Whilelmina Maria Rensen, +29

Journal of Medicinal Chemistry

New Pyrrole Derivatives with Potent Tubulin Polymerization Inhibiting Activity As Anticancer Agents Including Hedgehog-Dependent Cancer

Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, +22

Journal of Medicinal Chemistry

Chemoprevention StrategyAnticancer AgentsTumor BiologyPotential Anticancer AgentsMedicinal Chemistry +15

New Nitrogen Containing Substituents at the Indole-2-carboxamide Yield High Potent and Broad Spectrum Indolylarylsulfone HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors

Giuseppe La Regina, Antonio Coluccia, Andrea Brancale, +11

Journal of Medicinal Chemistry

Bioorganic ChemistryNew IndolylarylsulfoneMolecular BiologyK103n Hiv-1Antiviral Drug +14

New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer

Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, +30

Journal of Medicinal Chemistry

Chemoprevention StrategyApoptosisImmunologyNk CellsCell Death +15

Indolylarylsulfones Carrying a Heterocyclic Tail as Very Potent and Broad Spectrum HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors

Valeria Famiglini, Giuseppe La Regina, Antonio Coluccia, +16

Journal of Medicinal Chemistry

Medicinal ChemistryHiv-1 WtAntiviral CompoundPharmaceutical ChemistryBiochemistry +13

Design, Synthesis, and Biological Evaluation of 1-Phenylpyrazolo[3,4-<i>e</i>]pyrrolo[3,4-<i>g</i>]indolizine-4,6(1<i>H</i>,5<i>H</i>)-diones as New Glycogen Synthase Kinase-3β Inhibitors

Valeria La Pietra, Giuseppe La Regina, Antonio Coluccia, +11

Journal of Medicinal Chemistry

Compound 18Pharmaceutical ChemistryPre-clinical PharmacologyTranslational PharmacologyMolecular Pharmacology +15

Discovery of 1,1′-Biphenyl-4-sulfonamides as a New Class of Potent and Selective Carbonic Anhydrase XIV Inhibitors

Giuseppe La Regina, Antonio Coluccia, Valeria Famiglini, +12

Journal of Medicinal Chemistry

Combinatorial ChemistryPharmaceutical ScienceNew 1,1'-BiphenylsulfonamidesOrganic ChemistryChemistry +15

New Inhibitors of Indoleamine 2,3-Dioxygenase 1: Molecular Modeling Studies, Synthesis, and Biological Evaluation

Antonio Coluccia, Sara Passacantilli, Valeria Famiglini, +9

Journal of Medicinal Chemistry

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors

Giuseppe La Regina, Ruoli Bai, Antonio Coluccia, +17

European Journal of Medicinal Chemistry

Medicinal ChemistryPotent Tubulin AssemblyMedicineDrug Discovery7-Heterocyclyl-1h-indole Derivatives +4

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

Adriano Mollica, Sveva Pelliccia, Valeria Famiglini, +18

Journal of Enzyme Inhibition and Medicinal Chemistry