Mark Frazzetto

Dissecting isoform selectivity of PI3K inhibitors: the role of non-conserved residues in the catalytic pocket

Mark Frazzetto, Cenk Suphioglu, Jiuxiang Zhu et al. · Biochemical Journal · 2008 · 49 citations · Full text

Life Sciences, Biochemistry, Pharmacology +16

Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibα

Susan L. Cranmer, Inna Pikovski, Pierre Mangin et al. · Biochemical Journal · 2005 · 43 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

CYT997: a novel orally active tubulin polymerization inhibitor with potent cytotoxic and vascular disrupting activity <i>in vitro</i> and <i>in vivo</i>

Christopher J. Burns, Emmanuelle Fantino, Ian Phillips et al. · Molecular Cancer Therapeutics · 2009 · 35 citations · Full text

Medicine, Oncology, Pharmacology +17

Thiophene inhibitors of PDE4: Crystal structures show a second binding mode at the catalytic domain of PDE4D2

Jacob L. Nankervis, Susanne Feil, Nancy C. Hancock et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 21 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Synthesis and Pharmacological Evaluation of 4-Iminothiazolidinones for Inhibition of PI3 Kinase

Jo‐Anne Pinson, Oleg Schmidt‐Kittler, Mark Frazzetto et al. · Australian Journal of Chemistry · 2012 · 15 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13