Selectivity and potency of the retroprogesterone dydrogesterone in vitro

Tea Lanišnik Rižner, Petra Brožič, C.W. Doucette, +6

Steroids

InfertilityHormonal ContraceptiveMedicineRetroprogesterone DydrogesteronePharmacology +2

Synthesis and Biological Evaluation of (6- and 7-Phenyl) Coumarin Derivatives as Selective Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1

Štefan Starčević, Petra Brožič, Samo Turk, +3

Journal of Medicinal Chemistry

Pharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryCoumarin CoreBiological Evaluation +16

Flavonoids and cinnamic acid derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 1

Petra Brožič, Petra Kocbek, Matej Sova, +5

Molecular and Cellular Endocrinology

Medicinal ChemistryPharmaceutical ChemistryBiochemistryNatural SciencesSecondary Metabolite +3

Nonsteroidal anti-inflammatory drugs and their analogues as inhibitors of aldo-keto reductase AKR1C3: New lead compounds for the development of anticancer agents

Stanislav Gobec, Petra Brožič, Tea Lanišnik Rižner

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryNonsteroidal Anti-inflammatory DrugsAldo-keto Reductase Akr1c3BiochemistryMedicine +8

Cinnamic acids as new inhibitors of 17β-hydroxysteroid dehydrogenase type 5 (AKR1C3)

Petra Brožič, Barbara Golob, Nataša Gomboc, +2

Molecular and Cellular Endocrinology

Molecular PharmacologyMedicinal ChemistryBiochemistryNatural SciencesMedicine +7

Phytoestrogens as inhibitors of the human progesterone metabolizing enzyme AKR1C1

Petra Brožič, Tina Šmuc, Stanislav Gobec, +1

Molecular and Cellular Endocrinology

Hormonal ContraceptiveBiochemistryMedicineHormonal ReceptorHuman Progesterone +6

New cyclopentane derivatives as inhibitors of steroid metabolizing enzymes AKR1C1 and AKR1C3

Bogdan Štefane, Petra Brožič, Matej Vehovc, +2

European Journal of Medicinal Chemistry

Pharmaceutical ScienceNew Cyclopentane DerivativesBiochemistryMedicineEnzymes Akr1c1 +6

Selective Inhibitors of Aldo-Keto Reductases AKR1C1 and AKR1C3 Discovered by Virtual Screening of a Fragment Library

Petra Brožič, Samo Turk, Adegoke O. Adeniji, +5

Journal of Medicinal Chemistry

Drug TargetAldo-keto ReductaseFragment LibraryChemical BiologyPharmaceutical Chemistry +15

Expression of human aldo-keto reductase 1C2 in cell lines of peritoneal endometriosis: Potential implications in metabolism of progesterone and dydrogesterone and inhibition by progestins

Nataša Beranič, Petra Brožič, Boris Brus, +3

The Journal of Steroid Biochemistry and Molecular Biology

Peritoneal EndometriosisMedicinePotential ImplicationsUterine ReceptivityGynecology +10

Derivatives of pyrimidine, phthalimide and anthranilic acid as inhibitors of human hydroxysteroid dehydrogenase AKR1C1

Petra Brožič, Jožko Cesar, Andreja Kovač, +5

Chemico-Biological Interactions

Medicinal ChemistryBioorganic ChemistryDerivativesBiochemistryAldehyde Dehydrogenase +10