James T. Downs

ATP induces the release of IL-1 from LPS-primed cells in vivo.

R. Griffiths, Ethan J. Stam, James T. Downs et al. · The Journal of Immunology · 1995 · 132 citations · Full text

Life Sciences, Biochemistry, Immunology +17

Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1<i>H</i>)-one Series of Potent<scp>d</scp>-Amino Acid Oxidase (DAAO) Inhibitors

Allen J. Duplantier, Stacey L. Becker, Michael J. Bohanon et al. · Journal of Medicinal Chemistry · 2009 · 110 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA

James T. Downs, C L Lane, Nestor B Nestor et al. · Journal of Immunological Methods · 2001 · 93 citations

Life Sciences, Molecular Biology, Pathology +8

Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody

Ivan G. Otterness, James T. Downs, C L Lane et al. · Matrix Biology · 1999 · 65 citations

Pharmacy, Immunology, Pathology +12

Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14

Julian Blagg, Mark C. Noe, Lilli A. Wolf‐Gouveia et al. · Bioorganic & Medicinal Chemistry Letters · 2005 · 59 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13