Impaired B and T Cell Antigen Receptor Signaling in p110δ PI 3-Kinase Mutant Mice

Klaus Okkenhaug, Antonio Bilancio, Géraldine Farjot, +9

Science

ImmunologyCell DeathImmunologic MechanismClass IaInflammation +15

Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer

Khaled Ali, Dalya R. Soond, Roberto Piñeiro, +11

Nature

Cancer ImmunosurveillanceT-regulatory CellImmunologyImmune RegulationCell Death +7

Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration

Mariona Graupera, Julie Guillermet‐Guibert, Lazaros C. Foukas, +12

Nature

Developmental BiologyAngiogenesisSignaling PathwayP110α IsoformEndothelial Cell Migration +6

Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation

Lazaros C. Foukas, Marc Claret, Wayne Pearce, +7

Nature

Signal TransductionSignaling PathwayCritical RolePhysiologyP110α Phosphoinositide-3-oh Kinase +10

Essential role for the p110δ phosphoinositide 3-kinase in the allergic response

Khaled Ali, Antonio Bilancio, Matthew J. Thomas, +14

Nature

AsthmaP110δ Phosphoinositide 3-KinaseMolecular PhysiologySignal TransductionAllergy +8

Cutting Edge: The Phosphoinositide 3-Kinase p110δ Is Critical for the Function of CD4+CD25+Foxp3+ Regulatory T Cells

Daniel T. Patton, Oliver A. Garden, Wayne Pearce, +8

The Journal of Immunology

The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock

Ezra Aksoy, Salma Taboubi, David Torres, +10

Nature Immunology

InflammationSignal TransductionSignaling PathwayCell RegulationApoptosis +10

Somatic activating mutations in <i>Pik3ca</i> cause sporadic venous malformations in mice and humans

Sandra D. Castillo, Elena Tzouanacou, May Zaw Thin, +25

Science Translational Medicine

Control of Axonal Growth and Regeneration of Sensory Neurons by the p110δ PI 3-Kinase

Britta J. Eickholt, Aminul I. Ahmed, Meirion Davies, +11

PLoS ONE

Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo

Khaled Ali, Montserrat Camps, Wayne Pearce, +7

The Journal of Immunology