Geniposide suppresses LPS-induced nitric oxide, PGE2 and inflammatory cytokine by downregulating NF-κB, MAPK and AP-1 signaling pathways in macrophages

Cao Jinjun, Fang Li, Hongyan Zhao, +10

International Immunopharmacology

InflammationCytokineLps-induced Nitric OxideAnti-inflammatoryInflammatory Disease +11

The citrus flavonoid naringenin confers protection in a murine endotoxaemia model through AMPK-ATF3-dependent negative regulation of the TLR4 signalling pathway

Xin Liu, Ning Wang, Shijun Fan, +7

Scientific Reports

Identification of a new anti-LPS agent, geniposide, from Gardenia jasminoides Ellis, and its ability of direct binding and neutralization of lipopolysaccharide in vitro and in vivo

Xinchuan Zheng, Dong Yang, Xin Liu, +7

International Immunopharmacology

BiochemistryBioassay-guided IsolationMedicineNew Anti-lps AgentDirect Binding +4

Artesunate in combination with oxacillin protect sepsis model mice challenged with lethal live methicillin-resistant Staphylococcus aureus (MRSA) via its inhibition on proinflammatory cytokines release and enhancement on antibacterial activity of oxacillin

Weiwei Jiang, Bin Li, Xinchuan Zheng, +7

International Immunopharmacology

InflammationAnti-inflammatoryHealth SciencesMedicineAntibacterial Activity +11

Kukoamine B, a novel dual inhibitor of LPS and CpG DNA, is a potential candidate for sepsis treatment

Xin Liu, Xinchuan Zheng, Ning Wang, +6

British Journal of Pharmacology

The direct anti-MRSA effect of emodin via damaging cell membrane

Ming Liu, Wei Peng, Rongxin Qin, +8

Applied Microbiology and Biotechnology

Cell MembraneBiochemistryMedicinePharmacologyOxidative Stress +1

Ulinastatin is a novel candidate drug for sepsis and secondary acute lung injury, evidence from an optimized CLP rat model

Ning Wang, Xin Liu, Xinchuan Zheng, +6

International Immunopharmacology

InflammationAcute Lung InjuryNovel Candidate DrugMedicineSepsis +5

The anti-sepsis activity of the components of Huanglian Jiedu Decoction with high lipid A-binding affinity

Guirong Chen, Yubin Xu, Jing Jing, +5

International Immunopharmacology

InflammationLipid AnalysisBiochemistryMedicineHuanglian Jiedu Decoction +3

Dual targets guided screening and isolation of Kukoamine B as a novel natural anti-sepsis agent from traditional Chinese herb Cortex lycii

Xin Liu, Xinchuan Zheng, Yupeng Long, +6

International Immunopharmacology

Bioassay-guided IsolationTraditional Chinese MedicineMedicineHerbal MedicineImmunology +7

Artesunate has its enhancement on antibacterial activity of β-lactams via increasing the antibiotic accumulation within methicillin-resistant Staphylococcus aureus (MRSA)

Weiwei Jiang, Bin Li, Xinchuan Zheng, +6

The Journal of Antibiotics

Antimicrobial Drug DiscoveryAntibiotic AccumulationMethicillin-resistant Staphylococcus AureusAntibioticsAntimicrobial Susceptibility +10